Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H18ClN3O2 |
| Molecular Weight | 247.722 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1CC[C@@H](CC1)NC(=O)N(CCCl)N=O
InChI
InChIKey=FVLVBPDQNARYJU-KYZUINATSA-N
InChI=1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)/t8-,9-
| Molecular Formula | C10H18ClN3O2 |
| Molecular Weight | 247.722 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A phase 2 evaluation of 1-(2-chloroethyl)-3-(4- methylcyclohexyl)-1-nitrosourea (NSC 95441) in patients with advanced breast cancer. | 1974 Jan |
|
| Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU. | 1976 Jan 31 |
|
| Enhancement by electron-affinic agents of the therapeutic effects of cytotoxic agents against the KHT tumor: structure-activity relationships. | 1982 Mar-Apr |
|
| Chemical cholecystitis after intrahepatic chemotherapy. The case for prophylactic cholecystectomy during pump placement. | 1986 Mar |
|
| Comparative nephrotoxicity of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU) and chlorozotocin: functional-structural correlations in the Fischer 344 rat. | 1986 Mar 15 |
|
| Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity. | 1986 Nov |
|
| Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. | 2000 May |
|
| Anticancer drug-induced kidney disorders. | 2001 Jan |
|
| 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU). | 2002 |
|
| 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. | 2004 |
|
| Randomized trial of adjuvant therapy in colon carcinoma: 10-year results of NSABP protocol C-01. | 2004 Aug 4 |
|
| Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas. | 2007 Oct |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:20:10 GMT 2023
by
admin
on
Fri Dec 15 18:20:10 GMT 2023
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| Record UNII |
EGU4CMI14D
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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33073-59-5
Created by
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EGU4CMI14D
Created by
admin on Fri Dec 15 18:20:10 GMT 2023 , Edited by admin on Fri Dec 15 18:20:10 GMT 2023
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95441
Created by
admin on Fri Dec 15 18:20:10 GMT 2023 , Edited by admin on Fri Dec 15 18:20:10 GMT 2023
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PRIMARY |