STIBOPHEN ANHYDROUS

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C6H2O8S2.5Na.Sb
Molecular Weight	769.119
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Sb+3].[O-]C1=C([O-])C(=CC(=C1)S([O-])(=O)=O)S([O-])(=O)=O.[O-]C2=C([O-])C(=CC(=C2)S([O-])(=O)=O)S([O-])(=O)=O

InChI

InChIKey=DZFMIYUMNRPCAB-UHFFFAOYSA-F

InChI=1S/2C6H6O8S2.5Na.Sb/c2*7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14;;;;;;/h2*1-2,7-8H,(H,9,10,11)(H,12,13,14);;;;;;/q;;5*+1;+3/p-8

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Sb
Molecular Weight	121.76
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H2O8S2
Molecular Weight	266.205
Charge	-4
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.whocc.no/atcvet/atcvet_index/?code=QR05CA07https://www.ncbi.nlm.nih.gov/pubmed/5295139 | https://www.ncbi.nlm.nih.gov/pubmed/14851220 | https://www.ncbi.nlm.nih.gov/pubmed/8898332
Curator's Comment: description was created based on several sources, including https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ef48d40-6d63-440b-a73c-46d89f425936

Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
ATP-dependent 6-phosphofructokinase 21 Target ID: Q27778 Gene ID: NA Gene Symbol: PFK Target Organism: Schistosoma mansoni (Blood fluke) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8898332 \| https://www.ncbi.nlm.nih.gov/pubmed/13446367	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Schistosomiasis 32 Sources: https://www.ncbi.nlm.nih.gov/pubmed/193200 https://www.ncbi.nlm.nih.gov/pubmed/193201 https://www.ncbi.nlm.nih.gov/pubmed/13268811 https://www.ncbi.nlm.nih.gov/pubmed/20292219	Curative		Approved 8429	Fuadin Approved Use Schistosomiasis
Unknown 2578

PubMed

Title	Date	PubMed
Evaluation of fuadin therapy in schistosomiasis japonica.	1951 Apr	14851220
Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes.	2012 Jul	22520151

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:22 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:22 GMT 2023`
Record UNII	EF31LJY4KN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

STIBOPHEN ANHYDROUS

Common Name

English

ANTIMONY PYROCATECHOL PENTASODIUM DISULFONATE

Common Name

English

STIBOFEN ANHYDROUS

Common Name

English

SODIUM ANTIMONY III BIS(PYROCATECHOL-2,4-DISULFONATE)

Common Name

English

1,3,2-BENZODIOXASTIBOLE-4,6-DISULFONIC ACID, 2-(2-HYDROXY-3,5-DISULFOPHENOXY)-, SODIUM SALT

Common Name

English

Code System Code Type Description

CAS

526-50-1

Created by admin on Fri Dec 15 15:35:22 GMT 2023 , Edited by admin on Fri Dec 15 15:35:22 GMT 2023

PRIMARY

ECHA (EC/EINECS)

245-943-0