NICTINDOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16N2O
Molecular Weight	264.3217
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C1=C(C(=O)C2=CC=CN=C2)C3=C(N1)C=CC=C3

InChI

InChIKey=SOOXXPIIPHUERK-UHFFFAOYSA-N

InChI=1S/C17H16N2O/c1-11(2)16-15(13-7-3-4-8-14(13)19-16)17(20)12-6-5-9-18-10-12/h3-11,19H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H16N2O
Molecular Weight	264.3217
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6624480 | https://www.ncbi.nlm.nih.gov/pubmed/7126994 | https://www.ncbi.nlm.nih.gov/pubmed/375247

Nictindole is a non-steroidal anti-inflammatory agent. It is a thromboxane synthetase inhibitor. Nictindole inhibits generation of TXA2 in human platelet rich plasma.

Approval Year

PubMed

Title	Date	PubMed
ATP-sensitive potassium channels and endogenous adenosine are involved in spinal antinociception produced by locus coeruleus stimulation.	2004 Aug	15527202

Sample Use Guides

In Vivo Use Guide

Cats: forty minutes after intravenous administration of nictindole (2 mg/kg) the formation of platelet depostis was reduced by half. Three hours after i.v. administration of nictindole at a dose of 20 mg/kg the remaining anti-platelet activity was 18% for nictindole as compared to its antithrombotic action, which was recorded 40 min after their administration.

Route of Administration: Intravenous

In Vitro Use Guide

ATP and adenosine (10(-5) and 10(-4) M) caused a moderate contraction of the guinea-pig trachea under resting tone. This effect was antagonized by nictindole (10(-7) M).

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:54:30 GMT 2023` Edited by `admin` on `Sat Dec 16 15:54:30 GMT 2023`
Record UNII	EDK3Z2X1IV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NICTINDOLE

Official Name

English

L-8027

Code

English

nictindole [INN]

Common Name

English

L 8027

Code

English

2-ISOPROPYLINDOL-3-YL 3-PYRIDYL KETONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257