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Description
Curator's Comment:: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21893226 | https://www.ncbi.nlm.nih.gov/pubmed/20014777 | https://www.ncbi.nlm.nih.gov/pubmed/21862726 | https://www.ncbi.nlm.nih.gov/pubmed/21030469

Farnesol, (2E,6E)- is an isoprenoid found in many aromatic plants and is also produced in humans, where it acts on numerous nuclear receptors and has received considerable attention due to its apparent anticancer properties. Farnesol is present in many essential oils such as citronella, neroli, cyclamen, lemon grass, tuberose, rose, musk, balsam, and tolu. It is used in perfumery to emphasize the odors of sweet floral perfumes. Its method of action for enhancing perfume scent is as a co-solvent that regulates the volatility of the odorants. It is especially used in lilac perfumes. Farnesol is a natural pesticide for mites and is a pheromone for several other insects. In a 1994 report released by five top cigarette companies, farnesol was listed as one of 599 additives to cigarettes. Farnesol has been suggested to function as a chemopreventative and anti-tumor agent. Farnesol is subject to restrictions on its use in perfumery as some people may become sensitized to it, however, the evidence that farnesol can cause an allergic reaction in humans is disputed.

Originator

Sources: Chemistry & Industry (London, United Kingdom) (1961), 1907-8

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
81.4 µM [IC50]
47.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Identification of a nuclear receptor that is activated by farnesol metabolites.
1995 Jun 2
The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol.
2000 Apr 2
Xol INXS: role of the liver X and the farnesol X receptors.
2001 Apr
Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D.
2001 Mar
Antimycobacterial plant terpenoids.
2001 Nov
Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.
2002 Jan 11
Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism.
2002 Mar 25
Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.
2004 Jul 16
Omega-hydroxylation of farnesol by mammalian cytochromes p450.
2004 Jun 1
Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol.
2005 Apr 15
Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention.
2008 Nov 25
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.
2011 Feb 3
Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats.
2011 Jul 15
Patents

Sample Use Guides

mice were maintained for 5 wk on adiet containing 0.25%, 0.5% farnesol
Route of Administration: Oral
The ER-positive MCF-7 breast cancer cell line and MDAMB-231 breast carcinoma cells (ATCC HTB-26) lacking ER expression were used for activity evaluation. Cells were cultured at 37C in a humidified 95% air and 5% CO2 atmosphere. One day after seeding, the culture medium was replaced by fresh SFM containing farnesol (10-200mkM, MP Biomedicals, Aurora, OH), 17b-estradiol (Sigma, St Louis, MO), 4-hydroxytamoxifen (Sigma, St Louis, MO), the raloxifen analog LY 117,018 (a gift from Eli Lilly & Co., Indianapolis, IN), fulvestrant (ICI 182,780, Tocris, Bristol, UK), ibandronate (a gift from Hoffmann-LaRoche, Basel, Switzerland), mevastatin (Sigma, St Louis, MO), or vehicle. Cells were treated for 1–3 days, with drugs alone or in combinations. The FXR activator farnesol, a mevalonate pathway intermediate, exerts a mitogenic effect on MCF-7 cells.
Substance Class Mixture
Created
by admin
on Sat Jun 26 20:51:26 UTC 2021
Edited
by admin
on Sat Jun 26 20:51:26 UTC 2021
Record UNII
EB41QIU6JL
Record Status Validated (UNII)
Record Version
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Name Type Language
FARNESOL
FCC   FHFI   HSDB   INCI   MI  
INCI  
Official Name English
NSC-60597
Code English
FARNESYL ALCOHOL
Common Name English
FCI-119A
Code English
FARNESOL [MI]
Common Name English
FEMA NO. 2478
Code English
NIKKOSOME
Common Name English
FARNESOL [FCC]
Common Name English
FARNESOL [FHFI]
Common Name English
FARNESOL [HSDB]
Common Name English
FARNESOL [INCI]
Common Name English
3,7,11-TRIMETHYL-2,6,10-DODECATRIEN-1-OL
Common Name English
2,6,10-DODECATRIEN-1-OL, 3,7,11-TRIMETHYL-
Common Name English
TRIMETHYL DODECATRIENOL
Common Name English
Classification Tree Code System Code
EC SCIENTIFIC COMMITTEE ON CONSUMER SAFETY OPINION SCCS/1459/11
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
EPA PESTICIDE CODE 128910
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
JECFA EVALUATION FARNESOL
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
CFR 21 CFR 172.515
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
Code System Code Type Description
EPA CompTox
4602-84-0
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
DRUG BANK
DB02509
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
EVMPD
SUB169860
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
MERCK INDEX
M5245
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY Merck Index
RXCUI
1362903
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY RxNorm
FDA UNII
EB41QIU6JL
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
HSDB
445
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
ECHA (EC/EINECS)
225-004-1
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
CAS
4602-84-0
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
MESH
D005204
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
WIKIPEDIA
FARNESOL
Created by admin on Sat Jun 26 20:51:26 UTC 2021 , Edited by admin on Sat Jun 26 20:51:26 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Definition References