POTASSIUM ASPARTATE ANHYDROUS

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H5NO4.K.H
Molecular Weight	171.193
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of POTASSIUM ASPARTATE ANHYDROUS

Structure Search

SMILES

[H+].[K+].N[C@@H](CC([O-])=O)C([O-])=O

InChI

InChIKey=TXXVQZSTAVIHFD-DKWTVANSSA-M

InChI=1S/C4H7NO4.K/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);/q;+1/p-1/t2-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H
Molecular Weight	1.0079
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H5NO4
Molecular Weight	131.0868
Charge	-2
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.worldcat.org/title/fundamentals-of-biochemistry-life-at-the-molecular-level/oclc/910538334Advances in Protein Chemistry (1945), v.2, p.308, retrieved from: https://books.google.ru/books?id=QRyhIaEwrngC
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/15703381 | https://www.ncbi.nlm.nih.gov/pubmed/3814227 | https://www.ncbi.nlm.nih.gov/pubmed/16061593

Disodium aspartate is used in organic biosynthesis.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Isoaspartyl peptidase/L-asparaginase 8 Target ID: Q7L266 Gene ID: 80150.0 Gene Symbol: ASRGL1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3334241 \| https://www.ncbi.nlm.nih.gov/pubmed/7056352	Interacts 323
Glutamate [NMDA] receptor 125 Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15703381	Activator 1430	18.4 µM [EC50]
Beta-glucuronidase 13 Target ID: P08236 Gene ID: 2990.0 Gene Symbol: GUSB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Opiate abstinence syndrome 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814227	Primary	Natural Metabolite	Unknown Approved Use Unknown
Neonatal jaundice 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593	Primary	Natural Metabolite	Unknown Approved Use Unknown

Doses

Dose	Population	Adverse events
6 g 1 times / day multiple, oral Highest studied dose Dose: 6 g, 1 times / day Route: oral Route: multiple Dose: 6 g, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/28841667	healthy, 22.4 ± 2.6 years n = 10 Health Status: healthy Age Group: 22.4 ± 2.6 years Sex: M Population Size: 10 Sources: https://pubmed.ncbi.nlm.nih.gov/28841667	Sources: https://pubmed.ncbi.nlm.nih.gov/28841667

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OAT1 599	Aspartoacylase 8 ASNS 8 ASCT2 12 ASCT1 8 SLC22A13 8 OAT1 326

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
OAT1 603	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: -	no

Drug as victim

Target	Modality	Activity
OAT1 326	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: -	no
ASCT1 8	substrate 3367 Sources: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02063.x Page: -	yes
ASCT2 12	substrate 3367 Sources: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02063.x Page: -	yes
ASNS 8	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S1096719215300421 Page: -	yes
Aspartoacylase 8	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/12706335/ Page: -	yes
SLC22A13 8	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/24147638/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:22660	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:22660
ChemicalBook	CB7233502	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7233502
MolPort	MolPort-001-781-456	https://www.molport.com/shop/molecule-link/MolPort-001-781-456
MolPort	MolPort-047-345-807	https://www.molport.com/shop/molecule-link/MolPort-047-345-807
eMolecules	478747	https://www.emolecules.com/cgi-bin/more?vid=478747

PubMed

Title	Date	PubMed
L-amino acid sensing by the extracellular Ca2+-sensing receptor.	2000 Apr 25	10781086
Characterization of the protective effects of melatonin and related indoles against alpha-naphthylisothiocyanate-induced liver injury in rats.	2001	11169730
Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver.	2001 Feb	11220638
Comparison of clinical, virologic and pathologic features in patients with acute hepatitis B and C.	2001 Feb	11207903
Endotoxin clearance and its relation to hepatic and renal disturbances in rats with liver cirrhosis.	2001 Feb	11169075
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection.	2001 Feb	11164702
Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen.	2001 Feb	11159857
Central infusions of the recombinant human prolactin receptor antagonist, S179D-PRL, delay the onset of maternal behavior in steroid-primed, nulliparous female rats.	2001 Feb	11159845
DNA-protein crosslinks induced by nickel compounds in isolated rat lymphocytes: role of reactive oxygen species and specific amino acids.	2001 Feb 1	11162780
Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin.	2001 Feb 12	11209947
Phosphorylation-induced change of the oligomerization state of alpha B-crystallin.	2001 Feb 16	11096101
A novel osteopontin-like protein is expressed in the trout ovary during ovulation.	2001 Feb 2	11165234
DNA recognition by the methyl-CpG binding domain of MeCP2.	2001 Feb 2	11035019
Quantitative analysis of immunogold labeling indicates low levels and non-vesicular localization of L-aspartate in rat primary afferent terminals.	2001 Feb 5	11135252
Maintenance of primary murine hepatocyte functions in multicomponent polymer capsules--in vitro cryopreservation studies.	2001 Jan	11211886
Characterization of peptide substrates and viral enzyme that affect the cleavage site specificity of the human spumaretrovirus proteinase.	2001 Jan	11210941
Structure activity relationship of antiproliferative N-acyl-aspartic acid dimethyl ester. 2. Variation of the aspartyl moiety.	2001 Jan	11210664
Use of intraosseous blood for repeated hematologic and biochemical analyses in healthy pigs.	2001 Jan	11197559
Chloroplast genetic engineering.	2001 Jan	11193734
Oxygen free radical generation in healthy blood donors and cardiac patients: the protective effect of allopurinol.	2001 Jan	11192309
Leukocyte filtration in the early reperfusion phase on cardiopulmonary bypass reduces myocardial injury.	2001 Jan	11192307
Elevation of hepatic transaminases after enoxaparin use: case report and review of unfractionated and low-molecular-weight heparin-induced hepatotoxicity.	2001 Jan	11191729
The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates.	2001 Jan	11181713
A comparison of the effect of nitroparacetamol and paracetamol on liver injury.	2001 Jan	11156555
Effect of early arterialization of the porcine liver allograft on reperfusion injury, hepatocellular injury, and endothelial cell dysfunction.	2001 Jan	11150419
Microdialysis study of amino acid neurotransmitters in the spinal dorsal horn of patients undergoing microsurgical dorsal root entry zone lesioning. Technical note.	2001 Jan	11147857
Pregnancy complicated by pre-eclampsia-eclampsia with HELLP syndrome.	2001 Jan	11146072
alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia.	2001 Jan	11123383
GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity.	2001 Jan 1	11136855
The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel.	2001 Jan 12	11035011
Propylene glycol toxicosis in a llama.	2001 Jan 15	11195832
Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase.	2001 Jan 16	11148029
The effect of ketamine hydrochloride anesthesia on basal and N-methyl-D,L-aspartate induced plasma prolactin secretion in the adult male rhesus monkey.	2001 Jan 19	11212871
Three-dimensional structure of Erwinia chrysanthemi pectin methylesterase reveals a novel esterase active site.	2001 Jan 26	11162105
Positive and negative strands of HCV-RNA in sera and peripheral blood mononuclear cells of chronically hemodialyzed patients.	2001 Jan-Feb	11208504
Vitamin B12 and hepatic enzyme serum levels correlate in male alcohol-dependent patients.	2001 Jan-Feb	11139412
Characterization, amino acid sequence and evolution of edema-inducing, basic phospholipase A2 from Trimeresurus flavoviridis venom.	2001 Jul	11223097
Serum hyaluronic acid as an early prognostic marker in biliary atresia.	2001 Mar	11226992
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.	2001 Mar 1	11230124
In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis.	2001 Mar 1	11182525
Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects.	2001 Mar 1	11169772
The N-terminal segment of recombinant porcine fructose-1,6-bisphosphatase participates in the allosteric regulation of catalysis.	2001 Mar 2	11096109
Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.	2001 Mar 30	11139584
Pathobiochemical mechanisms involved in the control of the disease caused by Trypanosoma congolense in African grey duiker (Sylvicapra grimmia).	2001 Mar 5	11182235

Patents

Sample Use Guides

In Vivo Use Guide

Aspartic acid is a nutrient component found in animal and vegetable sources. In clinical trials to alleviate opioid abstinence it was administered orally.

Route of Administration: Oral

In Vitro Use Guide

Activation of recombinant NMDA receptors was measured using two-electrode voltage clamp. Current and voltage electrodes were made from thin-walled borosilicate glass using a PP-830 electrode puller and when filled with 3 M KCl, possessed resistances of between 0.5 and 1.5 MΩ. Oocytes were voltage-clamped at potentials of -40 mV. Aspartate was able to activate wild type NR1/NR2A NMDA receptors with EC50 of 18.4 uM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:50:31 GMT 2023` Edited by `admin` on `Fri Dec 15 17:50:31 GMT 2023`
Record UNII	E9VW2509NH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

POTASSIUM ASPARTATE ANHYDROUS

Common Name

English

POTASSIUM L-ASPARTATE [JAN]

Common Name

English

L-ASPARTIC ACID, MONOPOTASSIUM SALT

Common Name

English

L-ASPARTIC ACID, POTASSIUM SALT (1:1)

Common Name

English

POTASSIUM L-ASPARTATE

Systematic Name

English

POTASSIUM HYDROGEN ASPARTATE

Systematic Name

English

MONOPOTASSIUM ASPARTATE

Systematic Name

English

L-ASPARTIC ACID MONOPOTASSIUM SALT

Common Name

English

ASPARTIC ACID MONOPOTASSIUM SALT

Common Name

English

MONOPOTASSIUM ASPARTATE ANHYDROUS

Common Name

English

L-ASPARTIC ACID POTASSIUM SALT

Common Name

English

MONOPOTASSIUM L-ASPARTATE

Systematic Name

English

ASPARTIC ACID, MONOPOTASSIUM SALT, L-

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID70273966