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Details

Stereochemistry ACHIRAL
Molecular Formula C6H6N4O2
Molecular Weight 166.1377
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 7-METHYLXANTHINE

SMILES

Cn1cnc2c1c(nc(n2)O)O

InChI

InChIKey=PFWLFWPASULGAN-UHFFFAOYSA-N
InChI=1S/C6H6N4O2/c1-10-2-7-4-3(10)5(11)9-6(12)8-4/h2H,1H3,(H2,8,9,11,12)

HIDE SMILES / InChI

Molecular Formula C6H6N4O2
Molecular Weight 166.1377
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

7-Methylxanthine is a methyl derivative of xanthine, found occasionally in human urine. 7-Methylxanthine is one of the purine components in urinary calculi. 7-methylxanthine (7-MX) is a metabolite of caffeine and theobromine, and has been shown to have low toxicity and no carcinogenic effects. 7-MX is known as a non-selective adenosine antagonist and has been shown to work against myopia. 7-MX has little effect on the proliferation or apoptosis of human RPE cells; however, 7-MX disturbs the proportion of cells in the G1 stage and inhibits the expression of ADORA1, ADORA2A, and ADORA2B in short-term treatment. 7-MX has been confirmed to reduce the severity of myopia and eye elongation induced by forming deprivation in guinea pigs and to counteract the thinning of the posterior sclera and of collagen fibrils induced by form deprivation. A clinical trial showed that 7-MX reduced eye elongation and myopia progression in childhood myopia.

Approval Year

PubMed

PubMed

TitleDatePubMed
Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin.
2001 Aug 15
Determination of urinary methylated purine pattern by high-performance liquid chromatography.
2001 Feb 10
Caffeine metabolism in a group of 67 patients with primary biliary cirrhosis.
2001 Jan
Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components.
2001 Jul
Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants.
2003 May
Catabolism of caffeine in plants and microorganisms.
2004 May 1
Acid-base properties of xanthosine 5'-monophosphate (XMP) and of some related nucleobase derivatives in aqueous solution: micro acidity constant evaluations of the (N1)H versus the (N3)H deprotonation ambiguity.
2004 Oct 11
Coffee and tomato share common gene repertoires as revealed by deep sequencing of seed and cherry transcripts.
2005 Dec
Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection.
2005 May 25
Degradation kinetics of caffeine and related methylxanthines by induced cells of Pseudomonas sp.
2007 Jul

Sample Use Guides

During a 12-months placebo-controlled trial, participants received one tablet every morning. The tablets had a diameter of 12 mm and a thickness of 3 mm. Active tablets contained 400 mg 7-MX. The peak serum concentration after an oral dose of 400 mg 7-MX in adults is around 20 umol/l with a half-life of 200 min.
Route of Administration: Oral
To observe the growth of cells treated with 7-MX, primary human RPE cells were incubated with different concentrations (from 1 nmol/l to 1 mmol/l) of 7-MX. No statistically significantly growth alteration was noted at 24, 72, and 96 h. A slightly decreased cell proliferation rate was seen with 100 umol/l 7-MX at 48 h, but without statistically significant differences compared to the other concentrations. To observe the effects of 7-MX on the mRNA levels of ADORs, RPE cells were cultured with 10 umol/l 7-MX for 24, 48, and 72 h.
Substance Class Chemical
Created
by admin
on Sat Jun 26 05:57:29 UTC 2021
Edited
by admin
on Sat Jun 26 05:57:29 UTC 2021
Record UNII
E9M81NJM6G
Record Status Validated (UNII)
Record Version
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Name Type Language
7-METHYLXANTHINE
Systematic Name English
1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-7-METHYL-
Systematic Name English
NSC-7861
Code English
METHYLXANTHINE, 7-
Systematic Name English
METHYL XANTHINE
INCI  
INCI  
Official Name English
HETEROXANTHINE
Common Name English
7-METHYLXANTHIN
Systematic Name English
METHYL XANTHINE [INCI]
Common Name English
Code System Code Type Description
PUBCHEM
68374
Created by admin on Sat Jun 26 05:57:30 UTC 2021 , Edited by admin on Sat Jun 26 05:57:30 UTC 2021
PRIMARY
FDA UNII
E9M81NJM6G
Created by admin on Sat Jun 26 05:57:30 UTC 2021 , Edited by admin on Sat Jun 26 05:57:30 UTC 2021
PRIMARY
CAS
552-62-5
Created by admin on Sat Jun 26 05:57:30 UTC 2021 , Edited by admin on Sat Jun 26 05:57:30 UTC 2021
PRIMARY
EPA CompTox
552-62-5
Created by admin on Sat Jun 26 05:57:30 UTC 2021 , Edited by admin on Sat Jun 26 05:57:30 UTC 2021
PRIMARY
ECHA (EC/EINECS)
209-019-0
Created by admin on Sat Jun 26 05:57:30 UTC 2021 , Edited by admin on Sat Jun 26 05:57:30 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> METABOLITE
PERCENT OF AMOUNT EXCRETED
MAJOR
PLASMA; URINE