Upinitatug Rilsodotin

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:41:46 GMT 2025` Edited by `admin` on `Tue Apr 01 23:41:46 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	E8US1SQ3B5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Q4MDA7821L

Preferred Name

English

Upinitatug Rilsodotin

Official Name

English

Immunoglobulin G1 [de-450-lysine], anti-(human sodium-dependent phosphate transport protein 2B) (human-Mus musculus monoclonal XMT-1535 ?1-chain), disulfide with human-Mus musculus monoclonal XMT-1535 ?-chain, dimer, thioether with N-(2-carboxyethyl)carb

Common Name

English

XMT-1536

Code

English

Upifitamab rilsodotin [WHO-DD]

Common Name

English

ANTIBODY-DRUG CONJUGATE ADC XMT-1536

Common Name

English

Upifitamab Rilsodotin

Common Name

English

upinitatug rilsodotin [INN]

Common Name

English

ANTI-NAPI2B ADC XMT-1536

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens SLC34A2 (solute carrier family 34 sodium phosphate member 2, sodium/phosphate cotransporter 2B, NaPi2b, NaPi3b, NAPI-3B)], monoclonal antibody, conjugated, via a thioether bond, to 3 to 5 flexible polymers PHF-

Common Name

English

ANTI-NAPI2B/AURISTATIN F-HPA ADC XMT-1536

Common Name

English

Code System Code Type Description

INN

11318

Created by admin on Tue Apr 01 23:41:46 GMT 2025 , Edited by admin on Tue Apr 01 23:41:46 GMT 2025

PRIMARY

NCI_THESAURUS

C147577

Created by admin on Tue Apr 01 23:41:46 GMT 2025 , Edited by admin on Tue Apr 01 23:41:46 GMT 2025

PRIMARY

FDA UNII

E8US1SQ3B5

Created by admin on Tue Apr 01 23:41:46 GMT 2025 , Edited by admin on Tue Apr 01 23:41:46 GMT 2025

PRIMARY

SMS_ID

300000027752

Created by admin on Tue Apr 01 23:41:46 GMT 2025 , Edited by admin on Tue Apr 01 23:41:46 GMT 2025

PRIMARY

CAS

2254119-00-9

Created by admin on Tue Apr 01 23:41:46 GMT 2025 , Edited by admin on Tue Apr 01 23:41:46 GMT 2025

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LEGACY_FDA_UNII

Q4MDA7821L

Created by admin on Tue Apr 01 23:41:46 GMT 2025 , Edited by admin on Tue Apr 01 23:41:46 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_215
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_135	3_195
4_23	4_88
4_135	4_195
1_223	3_215
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					S2WV6E8K0X

SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B

TARGET->CONJUGATED TOXIN

Amount:


					7A55BK9DV3

XMT-1267

TOXIN -> CONJUGATE

Amount:

Related Record Type Details


					7A55BK9DV3

XMT-1267

METABOLITE ACTIVE -> PARENT

Amount:

Related Record Type Details


					E8US1SQ3B5

Upinitatug Rilsodotin

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC			UNSPECIFIED SUBSTANCE	ca525170 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:WEIGHT AVERAGE	CHEMICAL
Molecular Formula	CHEMICAL