CENTPIPERALONE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N4O.C2H4O2
Molecular Weight	290.3177
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CENTPIPERALONE

Structure Search

SMILES

CC(O)=O.O=C1NC(=NC2=CC=CC=C12)N3CCNCC3

InChI

InChIKey=NGEOOZRNZHUVFZ-UHFFFAOYSA-N

InChI=1S/C12H14N4O.C2H4O2/c17-11-9-3-1-2-4-10(9)14-12(15-11)16-7-5-13-6-8-16;1-2(3)4/h1-4,13H,5-8H2,(H,14,15,17);1H3,(H,3,4)

HIDE SMILES / InChI

Molecular Formula	C2H4O2
Molecular Weight	60.052
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C12H14N4O
Molecular Weight	230.2658
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Insulin secretion 1 Target ID: map04911 Sources: https://www.ncbi.nlm.nih.gov/pubmed/788428	Modulator 828

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:48:29 GMT 2023` Edited by `admin` on `Sat Dec 16 10:48:29 GMT 2023`
Record UNII	E62XS34V5I
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CENTPIPERALONE

Common Name

English

ACETIC ACID; 2-PIPERAZIN-1-YL-3H-QUINAZOLIN-4-ONE

Systematic Name

English

NSC-327690

Code

English

2-PIPERAZINO-4(3H)-QUINAZOLINONE MONOACETATE

Systematic Name

English

4(3H)-QUINAZOLINONE, 2-(1-PIPERAZINYL)-, ACETATE (1:1)

Systematic Name

English

Code System Code Type Description

MANUFACTURER PRODUCT INFORMATION

CENTPIPERALONE

Created by admin on Sat Dec 16 10:48:29 GMT 2023 , Edited by admin on Sat Dec 16 10:48:29 GMT 2023

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22587-29-7(centpiperalone) Product Description

PUBCHEM

135449338

Created by admin on Sat Dec 16 10:48:29 GMT 2023 , Edited by admin on Sat Dec 16 10:48:29 GMT 2023

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EPA CompTox

DTXSID90177114

Created by admin on Sat Dec 16 10:48:29 GMT 2023 , Edited by admin on Sat Dec 16 10:48:29 GMT 2023

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NSC

327690

Created by admin on Sat Dec 16 10:48:29 GMT 2023 , Edited by admin on Sat Dec 16 10:48:29 GMT 2023

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CAS

22587-29-7

Created by admin on Sat Dec 16 10:48:29 GMT 2023 , Edited by admin on Sat Dec 16 10:48:29 GMT 2023

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FDA UNII

E62XS34V5I

Created by admin on Sat Dec 16 10:48:29 GMT 2023 , Edited by admin on Sat Dec 16 10:48:29 GMT 2023

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Related Record Type Details


					E62XS34V5I

ACTIVE MOIETY

Comments:

The insulin releasing effect of Centpiperalone (CP) leading to blood sugar lowering has been established. Presently, CP-induced changes on insulin biosynthesis has been studied in isolated rat islets. CP at 1 hr incubation acts mainly on insulin liberation but after 3 hr, it partly stimulates (pro) insulin biosynthesis along with the induction of cathepsin-B enzyme. During simultaneous use of CP and D-glucose at optimum concentrations, decrease in 3H-leucine incorporation in insulin was seen in comparison to values obtained by use of CP alone. The results suggest that CP not only stimulates insulin release profoundly but also directly or indirectly enhances insulin biosynthesis.