Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C31H48N4O7S |
| Molecular Weight | 620.8 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CSC[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)N2CCOCC2)C(=O)N[C@@H](CC3CCCCC3)[C@@H](O)C(=O)OC(C)C
InChI
InChIKey=UZQBKCWYZBHBOW-YIPNQBBMSA-N
InChI=1S/C31H48N4O7S/c1-21(2)42-30(39)27(36)24(18-22-10-6-4-7-11-22)32-29(38)26(20-43-3)33-28(37)25(19-23-12-8-5-9-13-23)34-31(40)35-14-16-41-17-15-35/h5,8-9,12-13,21-22,24-27,36H,4,6-7,10-11,14-20H2,1-3H3,(H,32,38)(H,33,37)(H,34,40)/t24-,25-,26-,27+/m0/s1
| Molecular Formula | C31H48N4O7S |
| Molecular Weight | 620.8 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Terlakiren (also known as CP80794) is a cysteinamide derivative patented by Pfizer Inc. as potent renin inhibitor. Terlakirens inhibitory potency against plasma renin of guinea pigs, dogs, and monkeys ranges from 0.3 to 0.7 nM. In preclinical models, Terlakiren caused significantly greater increases in renal blood flow and suppressed renin activity to a greater degree than captopril.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Quantitation of 4-cyclohexyl-2-hydroxy-3-(3-methylsulfanyl-2- [2-[(morpholine-4-carbonyl)amino]-3-phenylpropionylamino]propi onylamino ) butyric acid isopropyl ester (CP-80,794), a renin inhibitor, and its hydrolytic cleavage metabolite 2-[(morpholine-4-carbonyl)amino]-3-phenylpropionic acid (CP-84,364) in dog and human plasma by high-performance liquid chromatography. | 1997-08-29 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:22:12 GMT 2025
by
admin
on
Mon Mar 31 19:22:12 GMT 2025
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| Record UNII |
E5H9IP637W
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Code | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C270
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C076964
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119625-78-4
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CHEMBL2105823
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DTXSID00152533
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E5H9IP637W
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6905
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SUB10926MIG
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100000082710
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C152568
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64922
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CC-69
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
