PNU-99194A

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H27NO2.ClH
Molecular Weight	313.863
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCCN(CCC)C1CC2=C(C1)C=C(OC)C(OC)=C2

InChI

InChIKey=NMBUOXDBNWBGIM-UHFFFAOYSA-N

InChI=1S/C17H27NO2.ClH/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;/h11-12,15H,5-10H2,1-4H3;1H

HIDE SMILES / InChI

Molecular Formula	C17H27NO2
Molecular Weight	277.4018
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D3 receptor 97 Target ID: CHEMBL234 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8129881	Antagonist 2849		78.0 nM [Ki]

PubMed

Title	Date	PubMed
Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin.	2010-08-15	20623619
Autoradiographic and pharmacological studies on the role of dopamine D3 receptors in genetically dystonic (dt(sz)) hamsters.	2010-08	20451545
Age-related differences in MK-801 induced behaviors in dopamine D3 receptor knock out mice.	2010-02-10	19909735
A functional role for the dopamine D3 receptor in the induction and expression of behavioural sensitization to ethanol in mice.	2009-11	19662386
D3 dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs.	2009-08	19390510
Dopamine modulates effort-based decision making in rats.	2009-04	19331447
Methamphetamine-induced locomotor activity and behavioral sensitization: are dopamine d3 receptors involved?	2007-05-15	17531156
Effects of 7-OH-DPAT and U 99194 on the behavioral response to hot plate test, in rats.	2006-11-30	16919688
Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking.	2006-07	16205775
Dopamine transporter blockade increases LTP in the CA1 region of the rat hippocampus via activation of the D3 dopamine receptor.	2006-04-06	16585791
Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.	2006-03-30	16573831
The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys.	2006-03	16631246
D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells.	2006-03	16401764
Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation.	2006-01	16162819
Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011.	2004-07	15252275
D(3) dopamine receptors are down-regulated in amphetamine sensitized rats and their putative antagonists modulate the locomotor sensitization to amphetamine.	2003-05-16	12711089
Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference.	2003-01-20	12544838
Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice.	2003-01	12451436
Dopamine D3 receptor antagonist effects on the motivational effects of ethanol.	2002-08	12377360
Common discriminative stimulus properties in rats of muscarinic antagonists, clozapine and the D3 preferring antagonist PNU-99194a: an analysis of possible mechanisms.	2001-09	11710745
Dopamine D3 receptors are involved in amphetamine-induced contralateral rotation in 6-OHDA lesioned rats.	2001-09	11566141
Antagonism of the discriminative stimulus effects of (+)-7-OH-DPAT by remoxipride but not PNU-99194A.	2001-03	11325388
Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen.	2001-01	10913686

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:33:54 GMT 2025` Edited by `admin` on `Mon Mar 31 22:33:54 GMT 2025`
Record UNII	E5A8B0V7P3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PNU-99194A

Common Name

English

U-99194A

Preferred Name

English

1H-INDEN-2-AMINE, 2,3-DIHYDRO-5,6-DIMETHOXY-N,N-DIPROPYL-, HYDROCHLORIDE

Systematic Name

English

1H-INDEN-2-AMINE, 2,3-DIHYDRO-5,6-DIMETHOXY-N,N-DIPROPYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

PUBCHEM

119195