Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H27NO2 |
| Molecular Weight | 277.4018 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCN(CCC)C1CC2=C(C1)C=C(OC)C(OC)=C2
InChI
InChIKey=UOLJKAPABHXFRE-UHFFFAOYSA-N
InChI=1S/C17H27NO2/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15/h11-12,15H,5-10H2,1-4H3
| Molecular Formula | C17H27NO2 |
| Molecular Weight | 277.4018 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin. | 2010-08-15 |
|
| Autoradiographic and pharmacological studies on the role of dopamine D3 receptors in genetically dystonic (dt(sz)) hamsters. | 2010-08 |
|
| Age-related differences in MK-801 induced behaviors in dopamine D3 receptor knock out mice. | 2010-02-10 |
|
| A functional role for the dopamine D3 receptor in the induction and expression of behavioural sensitization to ethanol in mice. | 2009-11 |
|
| D3 dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs. | 2009-08 |
|
| Dopamine modulates effort-based decision making in rats. | 2009-04 |
|
| Methamphetamine-induced locomotor activity and behavioral sensitization: are dopamine d3 receptors involved? | 2007-05-15 |
|
| Effects of 7-OH-DPAT and U 99194 on the behavioral response to hot plate test, in rats. | 2006-11-30 |
|
| Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. | 2006-07 |
|
| Dopamine transporter blockade increases LTP in the CA1 region of the rat hippocampus via activation of the D3 dopamine receptor. | 2006-04-06 |
|
| Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. | 2006-03-30 |
|
| The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. | 2006-03 |
|
| D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells. | 2006-03 |
|
| Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation. | 2006-01 |
|
| Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011. | 2004-07 |
|
| D(3) dopamine receptors are down-regulated in amphetamine sensitized rats and their putative antagonists modulate the locomotor sensitization to amphetamine. | 2003-05-16 |
|
| Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference. | 2003-01-20 |
|
| Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice. | 2003-01 |
|
| Dopamine D3 receptor antagonist effects on the motivational effects of ethanol. | 2002-08 |
|
| Common discriminative stimulus properties in rats of muscarinic antagonists, clozapine and the D3 preferring antagonist PNU-99194a: an analysis of possible mechanisms. | 2001-09 |
|
| Dopamine D3 receptors are involved in amphetamine-induced contralateral rotation in 6-OHDA lesioned rats. | 2001-09 |
|
| Antagonism of the discriminative stimulus effects of (+)-7-OH-DPAT by remoxipride but not PNU-99194A. | 2001-03 |
|
| Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen. | 2001-01 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:33:54 GMT 2025
by
admin
on
Mon Mar 31 22:33:54 GMT 2025
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| Record UNII |
929J96FO8T
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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5626
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82668-33-5
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929J96FO8T
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PNU-99,194
Created by
admin on Mon Mar 31 22:33:54 GMT 2025 , Edited by admin on Mon Mar 31 22:33:54 GMT 2025
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DTXSID50274471
Created by
admin on Mon Mar 31 22:33:54 GMT 2025 , Edited by admin on Mon Mar 31 22:33:54 GMT 2025
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