COFORMYCIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H16N4O5
Molecular Weight	284.2685
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=NC3=C2N=CNC[C@H]3O

InChI

InChIKey=YOOVTUPUBVHMPG-LODYRLCVSA-N

InChI=1S/C11H16N4O5/c16-2-6-8(18)9(19)11(20-6)15-4-14-7-5(17)1-12-3-13-10(7)15/h3-6,8-9,11,16-19H,1-2H2,(H,12,13)/t5-,6-,8-,9-,11-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C11H16N4O5
Molecular Weight	284.2685
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Reversion in Chinese hamster lines amplified at the AMPD2 locus: spontaneous and benzamide-stimulated gradual loss of amplified alleles of marker genes.	1996 Jan 17	8569793
Antifungal activity of 3'-deoxyadenosine (cordycepin).	1998 Jun	9624488
Binding thermodynamics of the transition state analogue coformycin and of the ground state analogue 1-deazaadenosine to bovine adenosine deaminase.	2001	11697042
Direct measurement of local and global contributions in the binding of coformycin to bovine adenosine deaminase.	2002 Apr	12420753
Enhancement of cellular adenosine triphosphate levels in PC12 cells by extracellular adenosine.	2002 Mar	11913523
Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells.	2002 May 20	11992407
Ring-expanded ("Fat") nucleosides as broad-spectrum anticancer and antiviral agents.	2002 Oct	12173969
Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.	2003 Aug 1	12874832
Enantiospecific synthesis of carbapentostatins.	2003 Jan 10	12515468
Inhibitors of adenosine deaminase: continued studies of structure-activity relationships in analogues of coformycin.	2004	15043152
Mechanisms of cell death induced by 2-chloroadenosine in leukemic B-cells.	2008 Apr 1	18242582
Divergence of AMP Deaminase in the Ice Worm Mesenchytraeus solifugus (Annelida, Clitellata, Enchytraeidae).	2009 Jul 5	21350654
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress.	2010 Dec 16	21187895

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:11:54 GMT 2023` Edited by `admin` on `Fri Dec 15 18:11:54 GMT 2023`
Record UNII	E49510ZL0H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COFORMYCIN

Common Name

English

IMIDAZO(4,5-D)(1,3)DIAZEPIN-8-OL, 3,4,7,8-TETRAHYDRO-3-.BETA.-D-RIBOFURANOSYL-, (8R)-

Systematic Name

English

NSC-277817

Code

English

Code System Code Type Description

CAS

11033-22-0