ZILEBESIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 10:24:35 GMT 2025` Edited by `admin` on `Wed Apr 02 10:24:35 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Type	COMPLETE
Record UNII	E422BH4BRK
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AD-85481

Preferred Name

English

ZILEBESIRAN

Official Name

English

zilebesiran [INN]

Common Name

English

ALN-85481

Code

English

[(2S,4R)-1-{1-[(2-acetamido-2-deoxy-?-D-galactopyranosyl)oxy]-16,16-bis({3-[(3-{5-[(2- acetamido-2-deoxy-?-D-galactopyranosyl)oxy]pentanamido}propyl)amino]-3-oxopropoxy}methyl)-5,11,18-trioxo-14-oxa-6,10,17- triazanonacosan-29-oyl}-4-hydroxypyrrolidin-2-

Common Name

English

ZILEBESIRAN [USAN]

Common Name

English

ALN-AGT01

Code

English

RNA, (Gm-sp-Um-sp-Cm-Am-Um-Cm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)A-Um-Gm-Am-Gm-Am-Gm-Um-Am-Cm-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-?-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acet

Common Name

English

Code System Code Type Description

CAS

2380166-33-4

Created by admin on Wed Apr 02 10:24:35 GMT 2025 , Edited by admin on Wed Apr 02 10:24:35 GMT 2025

PRIMARY

INN

11531

Created by admin on Wed Apr 02 10:24:35 GMT 2025 , Edited by admin on Wed Apr 02 10:24:35 GMT 2025

PRIMARY

SMS_ID

300000037422

Created by admin on Wed Apr 02 10:24:35 GMT 2025 , Edited by admin on Wed Apr 02 10:24:35 GMT 2025

PRIMARY

USAN

KL-80

Created by admin on Wed Apr 02 10:24:35 GMT 2025 , Edited by admin on Wed Apr 02 10:24:35 GMT 2025

PRIMARY

FDA UNII

E422BH4BRK

Created by admin on Wed Apr 02 10:24:35 GMT 2025 , Edited by admin on Wed Apr 02 10:24:35 GMT 2025

PRIMARY

NCI_THESAURUS

C179136

Created by admin on Wed Apr 02 10:24:35 GMT 2025 , Edited by admin on Wed Apr 02 10:24:35 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2;1_14;1_16;2_7;2_9-2_11	7 / 45
2'-O-Methyl-Ribose	1_1;1_3-1_13;1_15;1_17-1_23;2_1-2_6;2_8;2_12-2_22	38 / 45

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_3;1_22-1_23;2_2-2_3	6 / 43
Phosphate	1_4-1_21;2_4-2_22	37 / 43

Related Record Type Details


					A8P3J9MPQ3

ZILEBESIRAN SODIUM

SALT/SOLVATE -> PARENT

Amount:


					MU4K37ZE5W

ANGIOTENSINOGEN

TARGET->INHIBITOR OF EXPRESSION

Amount:

Related Record Type Details


					E422BH4BRK

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_6]				1-((2S)-1-(2,3-DIHYDROXY)PROPYL)THYMINE-PHOSPHATE	3BH2CF5QM5
NUCLEOTIDE SUBSTITUTION	[2_22]				ZILEBESIRAN 3'-MODIFICATION	UM4X8S48E7