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Details

Stereochemistry ABSOLUTE
Molecular Formula C16H20INO2
Molecular Weight 382.2417
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOMETOPANE I-124

SMILES

COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1C3=CC=C([124I])C=C3)N2C

InChI

InChIKey=SIIICDNNMDMWCI-IWFZPERZSA-N
InChI=1S/C16H20INO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3/t12-,13+,14+,15-/m0/s1/i17-3

HIDE SMILES / InChI
Molecular Formula C16H20INO2
Molecular Weight 382.2417
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Iometopane (RTI-55, beta-CIT) is a cocaine congener, binding to the neuronal dopamine and serotonin reuptake transporters affinity of Kd = 0.3 nM. Radiopharmaceutical forms of RTI-55 are used in single-photon emission computer tomography. Radioisotops 123I and 125I are favored, but 124I also used as a positron emitter to diagnose Parkinson's Disease.

CNS Activity

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Unexpected detection of melanoma brain metastasis by PET with iodine-124 betaCIT.
2009-10
N.c.a. radiosynthesis of [123,124I]beta-CIT, plasma analysis and pharmacokinetic studies with SPECT and PET.
1995-11
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:05:41 GMT 2025
Edited
by admin
on Mon Mar 31 23:05:41 GMT 2025
Record UNII
E3F4W5J90T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RTI-55 I-124
Preferred Name English
IOMETOPANE I-124
Common Name English
8-AZABICYCLO(3.2.1)OCTANE-2-CARBOXYLIC ACID, 3-(4-(IODO-124I)PHENYL)-8-METHYL-, METHYL ESTER, (1R-(EXO,EXO))-
Systematic Name English
IODINE (124I) 2-BETA-CARBOMETHOXY-3BETA-(4-IODOPHENYL)-TROPANE
Common Name English
IODINE (124I) 2.BETA.-CARBOMETHOXY-3.BETA.-(4 IODOPHENYL)-TROPANE
Systematic Name English
Classification Tree Code System Code
WHO-VATC QV09AX03
Created by admin on Mon Mar 31 23:05:41 GMT 2025 , Edited by admin on Mon Mar 31 23:05:41 GMT 2025
WHO-ATC V09AX03
Created by admin on Mon Mar 31 23:05:41 GMT 2025 , Edited by admin on Mon Mar 31 23:05:41 GMT 2025
Code System Code Type Description
EPA CompTox
DTXSID30905115
Created by admin on Mon Mar 31 23:05:41 GMT 2025 , Edited by admin on Mon Mar 31 23:05:41 GMT 2025
PRIMARY
PUBCHEM
46847940
Created by admin on Mon Mar 31 23:05:41 GMT 2025 , Edited by admin on Mon Mar 31 23:05:41 GMT 2025
PRIMARY
SMS_ID
300000051775
Created by admin on Mon Mar 31 23:05:41 GMT 2025 , Edited by admin on Mon Mar 31 23:05:41 GMT 2025
PRIMARY
CAS
173790-42-6
Created by admin on Mon Mar 31 23:05:41 GMT 2025 , Edited by admin on Mon Mar 31 23:05:41 GMT 2025
PRIMARY
WIKIPEDIA
RTI-55
Created by admin on Mon Mar 31 23:05:41 GMT 2025 , Edited by admin on Mon Mar 31 23:05:41 GMT 2025
PRIMARY
FDA UNII
E3F4W5J90T
Created by admin on Mon Mar 31 23:05:41 GMT 2025 , Edited by admin on Mon Mar 31 23:05:41 GMT 2025
PRIMARY
Related Record Type Details
Structure of IOMETOPANE
NON-LABELED -> LABELED
Related Record Type Details
Structure of IOMETOPANE I-124
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