Details
Stereochemistry | RACEMIC |
Molecular Formula | C19H24N2O4 |
Molecular Weight | 344.4049 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(C=CC=C1)N2CCN(CC(O)C3=CC(O)=C(O)C=C3)CC2
InChI
InChIKey=QESTYTNSJJTQCI-UHFFFAOYSA-N
InChI=1S/C19H24N2O4/c1-25-19-5-3-2-4-15(19)21-10-8-20(9-11-21)13-18(24)14-6-7-16(22)17(23)12-14/h2-7,12,18,22-24H,8-11,13H2,1H3
Molecular Formula | C19H24N2O4 |
Molecular Weight | 344.4049 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Pipratecol is substituted thienoimidazole. It is the H+/K(+)-ATPase inhibitor. In a high concentration of 10(-4) g/ml, pipratecol increased the amplitude of isolated guinea-pig atrial contractions while decreased the rate. But, in a low concentration of 10(-8) g/ml, the drug decrease the amplitude and increased the rate slightly. The effects of adrenaline and noradrenaline were suppressed by the preceding addition of pipratecol, while that of isoproterenol was scarcely. The effect of pipratecol on atrial contractions was hardly influenced by reserpine with which the animal had been pretreated 24 hours before the sacrifice of animal. The augmentative effect of nicotine on atrial contractions was slightly suppressed by the preceding addition of pipratecol. From these results, it was assumed that pipratecol has some affinity with the adrenergic receptor of atria. As a peripheral vasodilator it has been used in conjunction with raubasine in the treatment of cerebrovascular disorders. Pipratecol was used as antiulcerative agent also.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
[Pharmacological study of pipratecol (JP 711) and of a pharmaceutical combination raubasine-JP 711]. | 1969 Nov |
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Effect of a Raubasine-Pipratecol association (Isosarpan) on the sympathetic control of cerebral circulation. | 1979 Feb |
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[Effect of raubasine and pipratecol on platelet aggregation and on the platelet release reaction]. | 1980 Feb 29 |
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Substituted thieno[3,4-d]imidazoles, a novel group of H+/K(+)-ATPase inhibitors. Differentiation of their inhibition characteristics from those of omeprazole. | 1990 Oct 23 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 15:51:24 GMT 2023
by
admin
on
Sat Dec 16 15:51:24 GMT 2023
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Record UNII |
E33L6C08A5
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C29707
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100000082199
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C66407
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2541
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |