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Details

Stereochemistry ACHIRAL
Molecular Formula C6H8N4O4
Molecular Weight 200.1521
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RONIDAZOLE

SMILES

CN1C(COC(N)=O)=NC=C1[N+]([O-])=O

InChI

InChIKey=PQFRTXSWDXZRRS-UHFFFAOYSA-N
InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)

HIDE SMILES / InChI
Molecular Formula C6H8N4O4
Molecular Weight 200.1521
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ronidazole is an antiprotozoal agent. Ronidazole and the other nitroimidazole derivatives damage DNA following reduction of the nitro group. It is used in veterinary for prevention and treatment of various infections including histomoniasis in turkeys, trichomoniasis in pigeons, genital trichomoniasis in cattle, haemorrhagic enteritis in pigs and Tritrichomonas foetus in cats.

Originator

Merck Sharp & Dohme
57
Curator's Comment: references retrieved from www.drugfuture.com/chemdata/ronidazole.html # Merck Sharp & Dohme Corp

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Binding Agent
1076
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
Unknown

Approved Use

Antiprotozoal agent used for prevention and treatment of various infections including histomoniasis in turkeys, trichomoniasis in pigeons, genital trichomoniasis in cattle, haemorrhagic enteritis in pigs and Tritrichomonas foetus in cats
PubMed

PubMed

TitleDatePubMed
Validation of a method for the detection and confirmation of nitroimidazoles and corresponding hydroxy metabolites in turkey and swine muscle by means of gas chromatography-negative ion chemical ionization mass spectrometry.
2001-09-15
Susceptibility of Encephalitozoon cuniculi to several drugs in vitro.
1995-06
Patents

Patents

CN103601325A
1
US3450710
1
US3459764
1
US4675337A
1

Sample Use Guides

In Vivo Use Guide
Ronidazole administered at 30 to 50 mg/kg orally twice daily for 2 weeks was capable of resolving diarrhea and eradicating infections of Tritrichomonas foetus in cats.
Route of Administration: Oral
In Vitro Use Guide
The activities of antiprotozoal compounds at concentrations ranging from 2 μg/ml to 500 μg/ml were determined via cell counts of D. fragilis trophozoites grown in dixenic culture. Ronidazole has Minimum lethal concentration (MLC), 8 to 16 μg/ml
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:56:38 GMT 2025
Edited
by admin
on Mon Mar 31 17:56:38 GMT 2025
Record UNII
E01R4M1063
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RONIDAZOLE
INN   MART.   MI   USAN  
USAN   INN  
Official Name English
NSC-757865
Preferred Name English
1-Methyl-5-nitroimidazole-2-methanol carbamate ester
Common Name English
RONIDAZOLE [MART.]
Common Name English
ronidazole [INN]
Common Name English
RONIDAZOLE [MI]
Common Name English
1H-IMIDAZOLE-2-METHANOL, 1-METHYL-5-NITRO-, CARBAMATE (ESTER)
Common Name English
RONIDAZOLE [USAN]
Common Name English
Classification Tree Code System Code
WHO-VATC QP51AA08
Created by admin on Mon Mar 31 17:56:38 GMT 2025 , Edited by admin on Mon Mar 31 17:56:38 GMT 2025
NCI_THESAURUS C277
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Code System Code Type Description
NSC
757865
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PRIMARY
CAS
7681-76-7
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PRIMARY
INN
2356
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PRIMARY
EVMPD
SUB10377MIG
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PRIMARY
MESH
D012385
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PRIMARY
NCI_THESAURUS
C152248
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PRIMARY
ChEMBL
CHEMBL290299
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PRIMARY
EPA CompTox
DTXSID6045400
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PRIMARY
RXCUI
1535498
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PRIMARY RxNorm
ECHA (EC/EINECS)
231-675-1
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PRIMARY
WIKIPEDIA
RONIDAZOLE
Created by admin on Mon Mar 31 17:56:38 GMT 2025 , Edited by admin on Mon Mar 31 17:56:38 GMT 2025
PRIMARY
FDA UNII
E01R4M1063
Created by admin on Mon Mar 31 17:56:38 GMT 2025 , Edited by admin on Mon Mar 31 17:56:38 GMT 2025
PRIMARY
MERCK INDEX
m9655
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PRIMARY Merck Index
CHEBI
141154
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PRIMARY
PUBCHEM
5094
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PRIMARY
DAILYMED
E01R4M1063
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PRIMARY
SMS_ID
100000084357
Created by admin on Mon Mar 31 17:56:38 GMT 2025 , Edited by admin on Mon Mar 31 17:56:38 GMT 2025
PRIMARY
Related Record Type Details
Structure of RONIDAZOLE
ACTIVE MOIETY
NIH
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