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Details

Stereochemistry RACEMIC
Molecular Formula C6H12O4
Molecular Weight 148.1571
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of KETHOXAL

SMILES

CCOC(C)C(=O)C(O)O

InChI

InChIKey=YRCRRHNVYVFNTM-UHFFFAOYSA-N
InChI=1S/C6H12O4/c1-3-10-4(2)5(7)6(8)9/h4,6,8-9H,3H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C6H12O4
Molecular Weight 148.1571
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

KETHOXAL, a butanone derivative, has antiviral and anaplasmosis properties. It reacts with guanine to create a stable covalent adduct. KETHOXAL interacts with 30S ribosomal subunits yielding inactive ribosomes.

Approval Year

PubMed

PubMed

TitleDatePubMed
Inactivation of virus nucleic acid with glyoxal derivatives.
1959 Feb
The reaction of guanine derivatives with 1,2-dicarbonyl compounds.
1966 Sep
Kethoxal--a potentially useful reagent for the determination of nucleotide sequences in single-stranded regions of transfer ribonucleic acid.
1967 Jun
Functional modification of 16S ribosomal RNA by kethoxal.
1972 Nov
Substance Class Chemical
Created
by admin
on Tue Oct 22 19:51:12 UTC 2019
Edited
by admin
on Tue Oct 22 19:51:12 UTC 2019
Record UNII
E00MDP82S4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KETHOXAL
MI   USAN  
USAN  
Official Name English
KETOXAL [INN]
Common Name English
3-ETHOXY-1,1-DIHYDROXY-2-BUTANONE
Systematic Name English
KETOXAL
INN  
INN  
Official Name English
KETHOXAL [USAN]
Common Name English
U-2032
Code English
KETHOXAL [MI]
Common Name English
2-BUTANONE, 3-ETHOXY-1,1-DIHYDROXY-
Systematic Name English
Code System Code Type Description
PUBCHEM
34006
Created by admin on Tue Oct 22 19:51:12 UTC 2019 , Edited by admin on Tue Oct 22 19:51:12 UTC 2019
PRIMARY
INN
2749
Created by admin on Tue Oct 22 19:51:12 UTC 2019 , Edited by admin on Tue Oct 22 19:51:12 UTC 2019
PRIMARY
CAS
27762-78-3
Created by admin on Tue Oct 22 19:51:12 UTC 2019 , Edited by admin on Tue Oct 22 19:51:12 UTC 2019
PRIMARY
EVMPD
SUB08379MIG
Created by admin on Tue Oct 22 19:51:12 UTC 2019 , Edited by admin on Tue Oct 22 19:51:12 UTC 2019
PRIMARY
MERCK INDEX
M6617
Created by admin on Tue Oct 22 19:51:12 UTC 2019 , Edited by admin on Tue Oct 22 19:51:12 UTC 2019
PRIMARY Merck Index
MESH
C005135
Created by admin on Tue Oct 22 19:51:12 UTC 2019 , Edited by admin on Tue Oct 22 19:51:12 UTC 2019
PRIMARY
ChEMBL
CHEMBL2106348
Created by admin on Tue Oct 22 19:51:12 UTC 2019 , Edited by admin on Tue Oct 22 19:51:12 UTC 2019
PRIMARY
NCI_THESAURUS
C83855
Created by admin on Tue Oct 22 19:51:12 UTC 2019 , Edited by admin on Tue Oct 22 19:51:12 UTC 2019
PRIMARY
Related Record Type Details
ACTIVE MOIETY