KETHOXAL

Details

Stereochemistry	RACEMIC
Molecular Formula	C6H12O4
Molecular Weight	148.1571
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(C)C(=O)C(O)O

InChI

InChIKey=YRCRRHNVYVFNTM-UHFFFAOYSA-N

InChI=1S/C6H12O4/c1-3-10-4(2)5(7)6(8)9/h4,6,8-9H,3H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C6H12O4
Molecular Weight	148.1571
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6035923 | https://www.ncbi.nlm.nih.gov/pubmed/5961865 | https://www.ncbi.nlm.nih.gov/pubmed/13628672 | https://www.ncbi.nlm.nih.gov/pubmed/4564202

KETHOXAL, a butanone derivative, has antiviral and anaplasmosis properties. It reacts with guanine to create a stable covalent adduct. KETHOXAL interacts with 30S ribosomal subunits yielding inactive ribosomes.

Approval Year

PubMed

Title	Date	PubMed
Functional modification of 16S ribosomal RNA by kethoxal.	1972-11	4564202
Kethoxal--a potentially useful reagent for the determination of nucleotide sequences in single-stranded regions of transfer ribonucleic acid.	1967-06	6035923
The reaction of guanine derivatives with 1,2-dicarbonyl compounds.	1966-09	5961865
Inactivation of virus nucleic acid with glyoxal derivatives.	1959-02	13628672

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:45:09 GMT 2025` Edited by `admin` on `Mon Mar 31 17:45:09 GMT 2025`
Record UNII	E00MDP82S4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KETOXAL

Preferred Name

English

KETHOXAL

Official Name

English

ketoxal [INN]

Common Name

English

3-Ethoxy-1,1-dihydroxy-2-butanone

Systematic Name

English

KETHOXAL [USAN]

Common Name

English

U-2032

Code

English

KETHOXAL [MI]

Common Name

English

2-BUTANONE, 3-ETHOXY-1,1-DIHYDROXY-

Systematic Name

English

Code System Code Type Description

FDA UNII

E00MDP82S4