KETHOXAL

Details

Stereochemistry	RACEMIC
Molecular Formula	C6H12O4
Molecular Weight	148.1571
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(C)C(=O)C(O)O

InChI

InChIKey=YRCRRHNVYVFNTM-UHFFFAOYSA-N

InChI=1S/C6H12O4/c1-3-10-4(2)5(7)6(8)9/h4,6,8-9H,3H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C6H12O4
Molecular Weight	148.1571
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6035923 | https://www.ncbi.nlm.nih.gov/pubmed/5961865 | https://www.ncbi.nlm.nih.gov/pubmed/13628672 | https://www.ncbi.nlm.nih.gov/pubmed/4564202

KETHOXAL, a butanone derivative, has antiviral and anaplasmosis properties. It reacts with guanine to create a stable covalent adduct. KETHOXAL interacts with 30S ribosomal subunits yielding inactive ribosomes.

Approval Year

PubMed

Title	Date	PubMed
Inactivation of virus nucleic acid with glyoxal derivatives.	1959 Feb	13628672
The reaction of guanine derivatives with 1,2-dicarbonyl compounds.	1966 Sep	5961865
Kethoxal--a potentially useful reagent for the determination of nucleotide sequences in single-stranded regions of transfer ribonucleic acid.	1967 Jun	6035923
Functional modification of 16S ribosomal RNA by kethoxal.	1972 Nov	4564202

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:03:57 UTC 2023` Edited by `admin` on `Fri Dec 15 15:03:57 UTC 2023`
Record UNII	E00MDP82S4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KETHOXAL

Official Name

English

ketoxal [INN]

Common Name

English

3-Ethoxy-1,1-dihydroxy-2-butanone

Systematic Name

English

KETOXAL

Official Name

English

KETHOXAL [USAN]

Common Name

English

U-2032

Code

English

KETHOXAL [MI]

Common Name

English

2-BUTANONE, 3-ETHOXY-1,1-DIHYDROXY-

Systematic Name

English

Code System Code Type Description

FDA UNII

E00MDP82S4