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Details

Stereochemistry RACEMIC
Molecular Formula C12H20N2O2S2
Molecular Weight 288.429
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHITURAL

SMILES

CCCC(C)C1(CCSC)C(=O)NC(=S)NC1=O

InChI

InChIKey=KEMCRVSPPRNENL-UHFFFAOYSA-N
InChI=1S/C12H20N2O2S2/c1-4-5-8(2)12(6-7-18-3)9(15)13-11(17)14-10(12)16/h8H,4-7H2,1-3H3,(H2,13,14,15,16,17)

HIDE SMILES / InChI

Molecular Formula C12H20N2O2S2
Molecular Weight 288.429
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

METHITURAL (as sodium salt) is a barbiturate derivative which was used as an ultrashort-acting intravenous anesthetic.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Neraval

Approved Use

Neraval is an ultra short-acting thiobarbiturate for intravenous administration. In doses of 10 cc. of a 5% solution it swiftly induces light anesthesia.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
35 mg/L
50 mg/kg bw single, intravenous
dose: 50 mg/kg bw
route of administration: Intravenous
experiment type: SINGLE
co-administered:
METHITURAL plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
PubMed

PubMed

TitleDatePubMed
Methitural sodium (neraval sodium): a new ultrashort acting intravenous anesthetic.
1956 Sep-Oct
Neraval, Evipal, Pentothal, Surital: A Clinical Evaluation.
1958 Apr
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:55:26 GMT 2023
Edited
by admin
on Sat Dec 16 17:55:26 GMT 2023
Record UNII
DZQ457UJ3Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METHITURAL
INN   MI  
INN  
Official Name English
5-(1-METHYLBUTYL)-5-(2-(METHYLTHIO)ETHYL)-2-THIOBARBITURIC ACID
Systematic Name English
METHITURAL [MI]
Common Name English
methitural [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C67084
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
Code System Code Type Description
FDA UNII
DZQ457UJ3Y
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
PUBCHEM
3032307
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID10861962
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104624
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
INN
547
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
MERCK INDEX
m7320
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Methitural
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
NCI_THESAURUS
C83956
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
CAS
467-43-6
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
EVMPD
SUB08851MIG
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
MESH
C005213
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
DRUG CENTRAL
3348
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
SMS_ID
100000081433
Created by admin on Sat Dec 16 17:55:26 GMT 2023 , Edited by admin on Sat Dec 16 17:55:26 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY