Zolacabtagene Autoleucel

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 20:10:53 GMT 2025` Edited by `admin` on `Wed Apr 02 20:10:53 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	cd4 and cd8 enriched t cells
Record UNII	DU963TX85S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Zolacabtagene Autoleucel

Official Name

English

BMS-986353

Preferred Name

English

CC-97540

Code

English

BMS-986353 is an investigational CD19-targeted CAR T-cell product. The CD19-specific CAR consists of a single-chain variable fragment (scFv) binding domain derived from a CD19-specific monoclonal antibody (mAb; FMC63), an IgG-derived hinge region, a CD28

Common Name

English

ZOLACABTAGENE AUTOLEUCEL [USAN]

Common Name

English

Code System Code Type Description

USAN

MN-86

Created by admin on Wed Apr 02 20:10:53 GMT 2025 , Edited by admin on Wed Apr 02 20:10:53 GMT 2025

PRIMARY

INN

13483

Created by admin on Wed Apr 02 20:10:53 GMT 2025 , Edited by admin on Wed Apr 02 20:10:53 GMT 2025

PRIMARY

SMS_ID

300000050484

Created by admin on Wed Apr 02 20:10:53 GMT 2025 , Edited by admin on Wed Apr 02 20:10:53 GMT 2025

PRIMARY

NCI_THESAURUS

C175049

Created by admin on Wed Apr 02 20:10:53 GMT 2025 , Edited by admin on Wed Apr 02 20:10:53 GMT 2025

PRIMARY

FDA UNII

DU963TX85S

Created by admin on Wed Apr 02 20:10:53 GMT 2025 , Edited by admin on Wed Apr 02 20:10:53 GMT 2025

PRIMARY

Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					DU963TX85S

Zolacabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
	facilitate the dissociation of Expamer and abrogate the activation signal	CHEMICAL		BIOTIN	6SO6U10H04
LENTIVIRAL TRANSFECTION	TRANSFECTION			UNSPECIFIED SUBSTANCE	ec691156

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					LISOCABTAGENE MARALEUCEL CAR-T RECEPTOR	E18VZQ3GB1
VECTOR EXPRESSED PROTEIN					UNSPECIFIED SUBSTANCE	1cd64bba (not in database)
INSERTED GENE EXPRESSION VECTOR					RELMACABTAGENE AUTOLEUCEL TRANSGENE INSERT	Q77GF33B7N

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ANTIGEN EXPRESSED	BIOLOGICAL		`ZLW14X2D30` CD3

ANTIGEN EXPRESSED	BIOLOGICAL		`2946IE3VYD` CD8

ANTIGEN EXPRESSED	BIOLOGICAL		`8OYI5QX0HL` T-CELL SURFACE GLYCOPROTEIN CD4