MESUDIPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H24N2O4S
Molecular Weight	376.47
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C(C)NC(C)=C(C1C2=CC=CN=C2SC)C(=O)OCC

InChI

InChIKey=DYGIPCPWPHKLMC-UHFFFAOYSA-N

InChI=1S/C19H24N2O4S/c1-6-24-18(22)14-11(3)21-12(4)15(19(23)25-7-2)16(14)13-9-8-10-20-17(13)26-5/h8-10,16,21H,6-7H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C19H24N2O4S
Molecular Weight	376.47
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3720845 | https://www.ncbi.nlm.nih.gov/pubmed/3708217 | https://www.ncbi.nlm.nih.gov/pubmed/6852110 | https://www.ncbi.nlm.nih.gov/pubmed/6601967

Mesudipine, a dihydropyridine analog, is a calcium antagonistic drug (slow channel blocker). It blocks electrical activity in smooth muscle cells and Purkinje fibers.

Approval Year

PubMed

Title	Date	PubMed
New dihydropyridine drug, nilvadipine, blocks the calcium slow action potential in rat-cultured aortic smooth muscle cells.	1986-05-13	3720845
Effects of calcium antagonistic drugs on the electrical activity of rabbit sino-atrial node.	1986-05	3708217
Comparison of the effects of several calcium antagonistic drugs on the electrical activity of guinea pig Purkinje fibers.	1983-03-25	6852110
Depression of contractions of rabbit aorta and guinea pig vena cava by mesudipine and other slow channel blockers.	1983	6601967

Sample Use Guides

In Vitro Use Guide

Mesudipine at 10 nM and 40 nM depressed the Vmax, amplitude and duration of the slow action potentials of guinea pig Purkinje fibers and abolished excitability within 11 min at 100 nM. At 100 nM, mesudipine blocked the slow action potentials earlier (within 3 min) at higher stimulation frequency (from the usual drive rate of 0.5-1.5 Hz).

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:07:58 GMT 2025` Edited by `admin` on `Mon Mar 31 18:07:58 GMT 2025`
Record UNII	DT27W93DFF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

mesudipine [INN]

Preferred Name

English

MESUDIPINE

Official Name

English

DIETHYL 1',4'-DIHYDRO-2',6'-DIMETHYL-2-(METHYLTHIO)(3,4'-BIPYRIDINE)-3',5'-DICARBOXYLATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333