AMMONIUM ALUM ANHYDROUS

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	Al.2O4S.H4N
Molecular Weight	237.145
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[NH4+].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O

InChI

InChIKey=LCQXXBOSCBRNNT-UHFFFAOYSA-K

InChI=1S/Al.H3N.2H2O4S/c;;2*1-5(2,3)4/h;1H3;2*(H2,1,2,3,4)/q+3;;;/p-3

HIDE SMILES / InChI

Molecular Formula	H3N
Molecular Weight	17.0305
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO4S
Molecular Weight	97.071
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Al
Molecular Weight	26.9815
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 42 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 32 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 54 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8429	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 40 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8429	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
Cardiovascular manifestations of aluminium phosphide intoxication.	1989 Sep	2632560
Aluminum fluoride inhibition of glucocorticoid receptor inactivation and transformation.	1990 Apr 10	2191718
Plasma renin activity in shock due to aluminium phosphide poisoning.	1990 Jun	2200784
Effect of aluminum phosphide on blood glucose level.	1999 Feb	9949483
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.	1999 May	10327022
Intravascular hemolysis in aluminium phosphide poisoning.	1999 Sep	10496516
Effect of N-acetylcysteine and L-NAME on aluminium phosphide induced cardiovascular toxicity in rats.	2001 Apr	11742581
Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients.	2006	16615671
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.	2006 Nov	17119290
Aluminum and Alzheimer's disease: a new look.	2006 Nov	17119287
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.	2007 Oct	17931164
Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area.	2009 May 17	19428954
Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome.	2011 Mar	21057909
Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.	2012 Nov 23	23041170
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.	2014 Sep	24906048

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:08 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:08 GMT 2023`
Record UNII	DPU64XYB1D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMMONIUM ALUM ANHYDROUS

Common Name

English

AMMONIUM ALUMINIUM SULFATE

Systematic Name

English

AMMONIUM ALUM [USP MONOGRAPH]

Common Name

English

INS NO.523

Code

English

ALUMINUM AMMONIUM SULFATE [MI]

Common Name

English

E-523

Code

English

SULFURIC ACID, ALUMINIUM AMMONIUM SALT (2:1:1)

Common Name

English

Ammonium aluminium sulfate [WHO-DD]

Common Name

English

ALUMINIUM AMMONIUM SULFATE ANHYDROUS

Common Name

English

NSC-146176

Code

English

AMMONIUM-ALUM

Common Name

English

ALUM, AMMONIUM, EXSICCATED

Common Name

English

ALUMINIUM AMMONIUM BIS(SULPHATE)

Systematic Name

English

ALUMINUM AMMONIUM SULFATE [HSDB]

Common Name

English

INS-523

Code

English

SULFURIC ACID, ALUMINUM AMMONIUM SALT (2:1:1)

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-523