AMMONIUM ALUM

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	Al.2O4S.12H2O.H4N
Molecular Weight	453.329
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[NH4+].O.O.O.O.O.O.O.O.O.O.O.O.[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O

InChI

InChIKey=WZUKKIPWIPZMAS-UHFFFAOYSA-K

InChI=1S/Al.H3N.2H2O4S.12H2O/c;;2*1-5(2,3)4;;;;;;;;;;;;/h;1H3;2*(H2,1,2,3,4);12*1H2/q+3;;;;;;;;;;;;;;;/p-3

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Al
Molecular Weight	26.9815
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H3N
Molecular Weight	17.0305
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 42 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 32 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 54 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8429	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 40 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8429	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.	1948 Apr 8	18911341
Cardiovascular manifestations of aluminium phosphide intoxication.	1989 Sep	2632560
Aluminum fluoride inhibition of glucocorticoid receptor inactivation and transformation.	1990 Apr 10	2191718
Plasma renin activity in shock due to aluminium phosphide poisoning.	1990 Jun	2200784
Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S.	1994 Nov 25	7961906
Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride.	2001 Jan	11730559
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.	2002	12511178
Bone cell mitogenic action of fluoroaluminate and aluminum fluoride but not that of sodium fluoride involves upregulation of the insulin-like growth factor system.	2002 May	11996908
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.	2003	12851164
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.	2003 Sep	14552065
Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain.	2003 Sep 15	14507471
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].	2004 Nov	15516810
Aluminum: new recognition of an old problem.	2005 Dec	16198633
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.	2005 Nov	16308486
Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients.	2006	16615671
Aluminum and Alzheimer's disease: a new look.	2006 Nov	17119287
Ototoxic effect of Burow solution applied to the guinea pig middle ear.	2007 Aug	17450104
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.	2007 Oct	17931164
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.	2007 Sep-Oct	17870524
Aluminum phosphide fatalities at mild exertion in asymptomatic children: a clue to understand the variations of the autopsy findings.	2009 Aug	19573839
Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area.	2009 May 17	19428954
Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome.	2011 Mar	21057909
Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.	2012 Nov 23	23041170
Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.	2013 Nov	23499988

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:09 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:09 GMT 2023`
Record UNII	5C36DRL9ZN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMMONIUM ALUM

Official Name

English

AMMONIUM ALUM DODECAHYDRATE [USP MONOGRAPH]

Common Name

English

ALUMINUM AMMONIUM SULFATE (AL(NH4)(SO4)2) DODECAHYDRATE

Common Name

English

SULFURIC ACID, ALUMINUM AMMONIUM-SALT, HYDRATE (2:1:1:12)

Systematic Name

English

ALUM, AMMONIUM POWDER

Common Name

English

ALUM,AMMONIUM

Common Name

English

ALUMINUM AMMONIUM SULFATE DODECAHYDRATE

Systematic Name

English

SULFURIC ACID, ALUMINIUM AMMONIUM SALT (2:1:1), DODECAHYDRATE

Common Name

English

AMMONIUM ALUM [INCI]

Common Name

English

ALUM,AMMONIUM POWDER [VANDF]

Common Name

English

SULFURIC ACID, ALUMINUM AMMONIUM SALT (2:1:1), DODECAHYDRATE

Common Name

English

AMMONIUM ALUM DODECAHYDRATE

Common Name

English

ALUM,AMMONIUM [VANDF]

Common Name

English

MONOALUMINUM MONOAMMONIUM-DISULFATE DODECAHYDRATE

Systematic Name

English

MONOALUMINUM MONOAMMONIUM DISULFATE DODECAHYDRATE

Systematic Name

English

ALUM,AMMONIUM POWDER

Common Name

English

ALUM, AMMONIUM

Common Name

English

ALUMINUM AMMONIUM SULFATE

Systematic Name

English

ALUMINUM AMMONIUM SULFATE DODECAHYDRATE [MI]

Common Name

English

ALUMINIUM AMMONIUM SULFATE

Systematic Name

English

ALUMINUM AMMONIUM SULPHATE DODECAHYDRATE

Systematic Name

English

ALUMINUM AMMONIUM SULFATE [FCC]

Common Name

English

SULFURIC ACID, ALUMINUM AMMONIUM SALT, HYDRATE (2:1:1:12)

Common Name

English

ALUMINUM AMMONIUM SULPHATE

Systematic Name

English

ALUMINIUM AMMONIUM SULFATE DODECAHYDRATE

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

98501