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Details

Stereochemistry ACHIRAL
Molecular Formula C2H2F4
Molecular Weight 102.0309
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NORFLURANE

SMILES

FCC(F)(F)F

InChI

InChIKey=LVGUZGTVOIAKKC-UHFFFAOYSA-N
InChI=1S/C2H2F4/c3-1-2(4,5)6/h1H2

HIDE SMILES / InChI

Molecular Formula C2H2F4
Molecular Weight 102.0309
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Norflurane (1,1,1,2-Tetrafluoroethane) is a non-flammable gas used primarily as a "high-temperature" refrigerant for domestic refrigeration and automobile air conditioners. Other uses include plastic foam blowing, as a cleaning solvent, a propellant for the delivery of pharmaceuticals (e.g. bronchodilators), wine cork removers, gas dusters, and in air driers for removing the moisture from compressed air. Liquid Norflurane absorbs a high amount of thermal energy from the environment during its evaporation at atmospheric pressure. Norflurane is commercially available as a liquid in pressurized cylinders or cans. Norflurane is used as a propellant for some metered dose inhalers and as an inhalational anesthetic agent in animal studies.

Approval Year

PubMed

PubMed

TitleDatePubMed
Medical aerosol propellant interference with infrared anaesthetic gas monitors.
2004 Jun
CH-stretching overtone spectroscopy of 1,1,1,2-tetrafluoroethane.
2005 Jun 23
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.
2006 Jul
Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure.
2006 Nov 1
Extrinsic allergic alveolitis with eosinophil infiltration induced by 1,1,1,2-tetrafluoroethane (HFC-134a): a case report.
2007
Cryosurgical treatment of gingival melanin pigmentation with tetrafluoroethane.
2007 Apr
Dynamic skin cooling with an environmentally compatible alternative cryogen during laser surgery.
2007 Dec
Stability and activity of lipase in subcritical 1,1,1,2-tetrafluoroethane (R134a).
2007 Dec
Determination of reference ultrasound parameters for model and hydrofluoroalkane propellants using high-resolution ultrasonic spectroscopy.
2008
Dental pulp testing: a review.
2009
A force field for 3,3,3-fluoro-1-propenes, including HFO-1234yf.
2010 Aug 12
Effect of repeated refrigerant spray applications using various carriers on pulpal temperature change.
2010 May-Jun
Symmetry measures of the electron density.
2010 Oct
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 15:19:32 UTC 2023
Edited
by admin
on Fri Dec 15 15:19:32 UTC 2023
Record UNII
DH9E53K1Y8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NORFLURANE
HSDB   II   INN   MART.   USAN   WHO-DD  
INN   USAN  
Official Name English
HFA-134A PROPELLANT
Code English
Norflurane [WHO-DD]
Common Name English
SOLKANE 134A
Brand Name English
HYDROFLUOROCARBON 134A
INCI  
INCI  
Official Name English
GENETRON 134A
Common Name English
FORANE 134A
Brand Name English
1,1,1,2-Tetrafluoroethane
Systematic Name English
norflurane [INN]
Common Name English
NORFLURANE [HSDB]
Common Name English
NORFLURANE [MART.]
Common Name English
FREON 134A
Common Name English
HFA 134A
Code English
R-134A
Code English
DYMEL 134A
Brand Name English
NORFLURANE [EP MONOGRAPH]
Common Name English
HFA-134-A
Code English
HYDROFLUOROCARBON 134A [INCI]
Common Name English
SUVA 134A
Common Name English
HFC-134A [MI]
Common Name English
NORFLURANE [USAN]
Common Name English
HFA-134A
Common Name English
NORFLURANE [II]
Common Name English
HFC-134A
MI  
Code English
TETRAFLUOROETHANE [VANDF]
Common Name English
ETHANE, 1,1,1,2-TETRAFLUORO-
Systematic Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 100895
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID1021324
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
NCI_THESAURUS
C77482
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
CONCEPT Industrial Aid
RXCUI
1311560
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PRIMARY RxNorm
CAS
811-97-2
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
ChEMBL
CHEMBL2104432
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
MESH
C063006
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
HSDB
6756
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
SMS_ID
100000083616
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
MERCK INDEX
m6020
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY Merck Index
INN
2401
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
DRUG BANK
DB13116
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
ECHA (EC/EINECS)
212-377-0
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
PUBCHEM
13129
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
EVMPD
SUB09367MIG
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
82
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
DAILYMED
DH9E53K1Y8
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
FDA UNII
DH9E53K1Y8
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY
WIKIPEDIA
1,1,1,2-Tetrafluoroethane
Created by admin on Fri Dec 15 15:19:32 UTC 2023 , Edited by admin on Fri Dec 15 15:19:32 UTC 2023
PRIMARY 1,1,1,2-tetrafluoroethane, R-134a, Forane 134a, Genetron 134a, Florasol 134a, Suva 134a or HFC-134a, also known as norflurane (INN), is a haloalkane refrigerant with thermodynamic properties similar to R-12 (dichlorodifluoromethane) but with insignificant ozone depletion potential. It has the formula CH2FCF3 and a boiling point of −26.3 ?C (−15.34 ?F) at atmospheric pressure. R-134a cylinders are colored light blue.[2] Attempts at phasing out its use as a refrigerant with substances that have lower global warming potentials, such as HFO-1234yf are underway.
Related Record Type Details
ACTIVE MOIETY