Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H2F4 |
| Molecular Weight | 102.0309 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FCC(F)(F)F
InChI
InChIKey=LVGUZGTVOIAKKC-UHFFFAOYSA-N
InChI=1S/C2H2F4/c3-1-2(4,5)6/h1H2
| Molecular Formula | C2H2F4 |
| Molecular Weight | 102.0309 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Norflurane (1,1,1,2-Tetrafluoroethane) is a non-flammable gas used primarily as a "high-temperature" refrigerant for domestic refrigeration and automobile air conditioners. Other uses include plastic foam blowing, as a cleaning solvent, a propellant for the delivery of pharmaceuticals (e.g. bronchodilators), wine cork removers, gas dusters, and in air driers for removing the moisture from compressed air. Liquid Norflurane absorbs a high amount of thermal energy from the environment during its evaporation at atmospheric pressure. Norflurane is commercially available as a liquid in pressurized cylinders or cans. Norflurane is used as a propellant for some metered dose inhalers and as an inhalational anesthetic agent in animal studies.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Microscopic structure of liquid 1-1-1-2-tetrafluoroethane (R134a) from Monte Carlo simulation. | 2010-10-28 |
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| Symmetry measures of the electron density. | 2010-10 |
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| A force field for 3,3,3-fluoro-1-propenes, including HFO-1234yf. | 2010-08-12 |
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| Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices. | 2010-06-28 |
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| Effect of repeated refrigerant spray applications using various carriers on pulpal temperature change. | 2010-05-19 |
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| Reproductive and developmental toxicity of hydrofluorocarbons used as refrigerants. | 2010-04 |
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| The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation. | 2010-03 |
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| Supercritical fluid extraction of polybrominated diphenyl ethers (PBDEs) from house dust with supercritical 1,1,1,2-tetrafluoroethane (R134a). | 2010-01-15 |
|
| Liquid-air partition coefficients of 1,1-difluoroethane (HFC152a), 1,1,1-trifluoroethane (HFC143a), 1,1,1,2-tetrafluoroethane (HFC134a), 1,1,1,2,2-pentafluoroethane (HFC125) and 1,1,1,3,3-pentafluoropropane (HFC245fa). | 2010-01 |
|
| Estimated 2017 refrigerant emissions of 2,3,3,3-tetrafluoropropene (HFC-1234yf) in the United States resulting from automobile air conditioning. | 2009-12-15 |
|
| Efficacy of lamellar resection, cryotherapy, and adjunctive grafting for the treatment of canine limbal melanoma. | 2009-11-07 |
|
| The validity of pulp testing: a clinical study. | 2009-08 |
|
| All-atom force field for the prediction of vapor-liquid equilibria and interfacial properties of HFA134a. | 2009-01-08 |
|
| Dental pulp testing: a review. | 2009 |
|
| Decomposition of hydrofluorocarbons in a dielectric-packed plasma reactor. | 2008-07-24 |
|
| Effect of topical aerosol skin refrigerant (spray and stretch technique) on passive and active stretching. | 2008-04 |
|
| Determination of reference ultrasound parameters for model and hydrofluoroalkane propellants using high-resolution ultrasonic spectroscopy. | 2008 |
|
| One-solvent extraction of astaxanthin from lactic acid fermented shrimp wastes. | 2007-12-12 |
|
| Dynamic skin cooling with an environmentally compatible alternative cryogen during laser surgery. | 2007-12 |
|
| Stability and activity of lipase in subcritical 1,1,1,2-tetrafluoroethane (R134a). | 2007-12 |
|
| Cryosurgical treatment of gingival melanin pigmentation with tetrafluoroethane. | 2007-04 |
|
| Extrinsic allergic alveolitis with eosinophil infiltration induced by 1,1,1,2-tetrafluoroethane (HFC-134a): a case report. | 2007 |
|
| Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure. | 2006-11-01 |
|
| Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. | 2006-07 |
|
| Probing the internal competition between alpha- and beta-elimination by fluorine substitution in adsorbed ethyl groups on Cu(100). | 2005-11-24 |
|
| A simple route to difluorocarbene and perfluoroalkylidene complexes of iridium. | 2005-11-02 |
|
| Nonablative remodeling with a 1,540 nm erbium:glass laser. | 2005-09 |
|
| CH-stretching overtone spectroscopy of 1,1,1,2-tetrafluoroethane. | 2005-06-23 |
|
| Application of the cell potential method to predict phase equilibria of multicomponent gas hydrate systems. | 2005-04-28 |
|
| Cold testing through full-coverage restorations. | 2004-10 |
|
| An atmospheric pressure chemical ionization study of the positive and negative ion chemistry of the hydrofluorocarbons 1,1-difluoroethane (HFC-152a) and 1,1,1,2-tetrafluoroethane (HFC-134a) and of perfluoro-n-hexane (FC-72) in air plasma at atmospheric pressure. | 2004-07 |
|
| Pulp responses to precise thermal stimuli in dentin-sensitive teeth. | 2004-06 |
|
| Medical aerosol propellant interference with infrared anaesthetic gas monitors. | 2004-06 |
|
| Application of magnetic resonance imaging to the investigation of the diffusivity of 1,1,1,2-tetrafluorethane in two polymers. | 2004-03 |
|
| Desflurane inhibits platelet function in vitro similar to halothane. | 2003-11 |
|
| Occupational exposure to fluorinated hydrocarbons during refrigeration repair work. | 2003-04 |
|
| Chemically assisted laser ablation ICP mass spectrometry. | 2003-01-15 |
|
| Characterisation of the aggregation behaviour in a salmeterol and fluticasone propionate inhalation aerosol system. | 2001-06-19 |
|
| Metering performance of several metered-dose inhalers with different spacers/holding chambers. | 2001 |
|
| Dominant role of cytochrome P-450 2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane. | 1992-07-11 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
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on
Mon Mar 31 17:54:07 GMT 2025
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| Record UNII |
DH9E53K1Y8
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| Record Status |
Validated (UNII)
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| Record Version |
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EPA PESTICIDE CODE |
100895
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DTXSID1021324
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C77482
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C45678
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CONCEPT | Industrial Aid | ||
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1311560
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C063006
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m6020
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DH9E53K1Y8
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1,1,1,2-Tetrafluoroethane
Created by
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PRIMARY | 1,1,1,2-tetrafluoroethane, R-134a, Forane 134a, Genetron 134a, Florasol 134a, Suva 134a or HFC-134a, also known as norflurane (INN), is a haloalkane refrigerant with thermodynamic properties similar to R-12 (dichlorodifluoromethane) but with insignificant ozone depletion potential. It has the formula CH2FCF3 and a boiling point of −26.3 ?C (−15.34 ?F) at atmospheric pressure. R-134a cylinders are colored light blue.[2] Attempts at phasing out its use as a refrigerant with substances that have lower global warming potentials, such as HFO-1234yf are underway. |
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ACTIVE MOIETY |
