Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H20N2O |
| Molecular Weight | 268.3535 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CCCN3CCC4=C(N([C@H](O)C1)C5=C4C=CC=C5)[C@]23[H]
InChI
InChIKey=KOIGYXJOGRVNIS-LYRGGWFBSA-N
InChI=1S/C17H20N2O/c20-15-10-11-4-3-8-18-9-7-13-12-5-1-2-6-14(12)19(15)17(13)16(11)18/h1-2,5-6,11,15-16,20H,3-4,7-10H2/t11-,15-,16+/m1/s1
| Molecular Formula | C17H20N2O |
| Molecular Weight | 268.3535 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Vindeburnol, a derivative of the plant alkaloid vincamine that that bears neuroprotective properties. Animal model for Alzheimer's disease has shown that vindeburnol reduced neuroinflammation and amyloid burden. In addition, the treatment with this drug can be of benefit in multiple sclerosis patients.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of the new eburnamenine derivative RU 24722 on EEG recovery and cerebral energy metabolism after complete ischemia. | 1985 |
|
| Enhanced tail pinch-induced activation of catecholamine metabolism in the pericerulean area of RU 24722-treated rats. | 2004 Dec 24 |
|
| The vincamine derivative vindeburnol provides benefit in a mouse model of multiple sclerosis: effects on the Locus coeruleus. | 2012 Apr |
|
| The locus coeruleus neuroprotective drug vindeburnol normalizes behavior in the 5xFAD transgenic mouse model of Alzheimer's disease. | 2019 Jan 1 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:11:34 GMT 2023
by
admin
on
Fri Dec 15 16:11:34 GMT 2023
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| Record UNII |
DFR7VWX42K
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C1509
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5293
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100000079109
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DFR7VWX42K
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SUB00060MIG
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68882
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68779-67-9
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C80883
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C044616
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DTXSID201270189
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CHEMBL2107237
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
