VINDEBURNOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20N2O
Molecular Weight	268.3535
Optical Activity	( + / - )
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CCCN3CCC4=C(N([C@H](O)C1)C5=C4C=CC=C5)[C@]23[H]

InChI

InChIKey=KOIGYXJOGRVNIS-LYRGGWFBSA-N

InChI=1S/C17H20N2O/c20-15-10-11-4-3-8-18-9-7-13-12-5-1-2-6-14(12)19(15)17(13)16(11)18/h1-2,5-6,11,15-16,20H,3-4,7-10H2/t11-,15-,16+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H20N2O
Molecular Weight	268.3535
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29274883 | https://www.ncbi.nlm.nih.gov/pubmed/22288774

Vindeburnol, a derivative of the plant alkaloid vincamine that that bears neuroprotective properties. Animal model for Alzheimer's disease has shown that vindeburnol reduced neuroinflammation and amyloid burden. In addition, the treatment with this drug can be of benefit in multiple sclerosis patients.

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:11:34 GMT 2023` Edited by `admin` on `Fri Dec 15 16:11:34 GMT 2023`
Record UNII	DFR7VWX42K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VINDEBURNOL

Official Name

English

EBURNAMENIN-14-OL, 14,15-DIHYDRO-, (3-.ALPHA.,14-.BETA.)-(±)-

Common Name

English

vindeburnol [INN]

Common Name

English

(±)-20,21-DINOR-16.ALPHA.-EBURNAMINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1509