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Details

Stereochemistry ABSOLUTE
Molecular Formula C11H13NO4
Molecular Weight 223.2252
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACETYL L-TYROSINE

SMILES

CC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

InChI

InChIKey=CAHKINHBCWCHCF-JTQLQIEISA-N
InChI=1S/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/t10-/m0/s1

HIDE SMILES / InChI
Molecular Formula C11H13NO4
Molecular Weight 223.2252
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14621123 and https://yurielkaim.com/n-acetyl-l-tyrosine/

N-Acetyltyrosine is an acetylated derivative of the amino acid L-tyrosine. Ordinary L-tyrosine is less stable and also less soluble in water, which may result in reduced bioavailability. Acetylation enhances the solubility and stability of certain amino acids. N-Acetyltyrosine is commonly used in place of tyrosine in parenteral nutrition. It converts to tyrosine and then can be used in neurotransmitter treatment as a precursor of cathecholamine. N-Acetyltyrosine supports brain function by supporting the synthesis of the catecholamines norepinephrine and dopamine (neurotransmitters). N-Acetyltyrosine supplements are used to improve memory and cognitive performance in humans while they are experiencing psychological stress.

CNS Activity

Approval Year

1984
98
Targets

Targets

Primary TargetPharmacologyConditionPotency
Staphylococcus aureus toxic shock syndrome toxin 1 production
1
Target ID: Staphylococcus aureus toxic shock syndrome toxin 1 production
Inhibitor
8297
Staphylococcus aureus growth
27
Target ID: Staphylococcus aureus growth
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
TrophAmine

Approved Use

TrophAmine is indicated for the nutritional support of infants (including those of low birth weight) and young pediatric patients requiring TPN via either central or peripheral infusion routes. Parenteral nutrition with TrophAmine is indicated to prevent nitrogen and weight loss or treat negative nitrogen balance in infants and young pediatric patients where (1) the alimentary tract, by the oral, gastrostomy, or jejunostomy route, cannot or should not be used, or adequate protein intake is not feasible by these routes; (2) gastrointestinal absorption of protein is impaired; or (3) protein requirements are substantially increased as with extensive burns.

Launch Date

4.59043209E11
PubMed

PubMed

TitleDatePubMed
N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition.
2003 Nov-Dec
Patents

Patents

20020037314
1
JP2003104835A
1
JP2009221152A
1

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Can also be injected, if N-Acetyltyrosine is an ingredient of hypertonic solutions containing crystalline amino acids for nutritional support and therapy http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/19018scs018_trophamine_lbl.pdf
The best dosage range of NALT (N-Acetyltyrosine) is between 200-500 mgs per day. This can be taken all at once or spread throughout your day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:22 UTC 2023
Edited
by admin
on Fri Dec 15 15:52:22 UTC 2023
Record UNII
DA8G610ZO5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ACETYL L-TYROSINE
Common Name English
N-ACETYLTYROSINE
EP  
Systematic Name English
(+)-(2S)-2-(ACETYLAMINO)-3-(4-HYDROXYPHENYL)PROPANOIC ACID
Systematic Name English
TYR-EXCEL
Brand Name English
L-N-ACETYLTYROSINE
Common Name English
N-ACETYLTYROSINE [EP MONOGRAPH]
Common Name English
L-TYROSINE, N-ACETYL
Common Name English
N-acetyltyrosin [WHO-DD]
Common Name English
N-ACETYL-L-TYROSINE [USP-RS]
Common Name English
ACETYL TYROSINE [INCI]
Common Name English
N-ACETYLTYROSIN
WHO-DD  
Systematic Name English
MELANOWHITE-A
Brand Name English
(2S)-2-ACETYLAMINO-3-(4-HYDROXYPHENYL)PROPANOIC ACID
Systematic Name English
N-ACETYL-L-TYROSINE
USP-RS  
Systematic Name English
TANOGEN HB
Brand Name English
NSC-10853
Code English
ACETYL TYROSINE
INCI  
INCI  
Official Name English
N-ACETYL-TYROSINE
Systematic Name English
Classification Tree Code System Code
DSLD 3506 (Number of products:19)
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
LOINC 79514-6
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
DSLD 3129 (Number of products:660)
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
LOINC 25119-9
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
LOINC 13780-2
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
LOINC 29632-7
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
NCI_THESAURUS C73539
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
Code System Code Type Description
NSC
10853
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
DRUG BANK
DB11102
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
PUBCHEM
68310
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
EPA CompTox
DTXSID7046045
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
NCI_THESAURUS
C61853
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
SMS_ID
100000088304
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
MESH
C025787
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
WIKIPEDIA
N-Acetyl-L-tyrosine
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
CHEBI
21563
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
FDA UNII
DA8G610ZO5
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
ECHA (EC/EINECS)
208-671-3
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
DAILYMED
DA8G610ZO5
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
EVMPD
SUB12166MIG
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
DRUG CENTRAL
4481
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
RS_ITEM_NUM
1010106
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
RXCUI
31005
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY RxNorm
CHEBI
68561
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
CAS
537-55-3
Created by admin on Fri Dec 15 15:52:23 UTC 2023 , Edited by admin on Fri Dec 15 15:52:23 UTC 2023
PRIMARY
Related Record Type Details
Structure of DIACETYLTYROSINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of TYROSINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of ACETYL L-TYROSINE
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