ACETYL L-TYROSINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H13NO4
Molecular Weight	223.2252
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

InChI

InChIKey=CAHKINHBCWCHCF-JTQLQIEISA-N

InChI=1S/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/t10-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C11H13NO4
Molecular Weight	223.2252
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.jarrow.com/product/65/N-Acetyl_Tyrosine
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14621123 and https://yurielkaim.com/n-acetyl-l-tyrosine/

N-Acetyltyrosine is an acetylated derivative of the amino acid L-tyrosine. Ordinary L-tyrosine is less stable and also less soluble in water, which may result in reduced bioavailability. Acetylation enhances the solubility and stability of certain amino acids. N-Acetyltyrosine is commonly used in place of tyrosine in parenteral nutrition. It converts to tyrosine and then can be used in neurotransmitter treatment as a precursor of cathecholamine. N-Acetyltyrosine supports brain function by supporting the synthesis of the catecholamines norepinephrine and dopamine (neurotransmitters). N-Acetyltyrosine supplements are used to improve memory and cognitive performance in humans while they are experiencing psychological stress.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Staphylococcus aureus toxic shock syndrome toxin 1 production 1 Target ID: Staphylococcus aureus toxic shock syndrome toxin 1 production Sources: http://www.ncbi.nlm.nih.gov/pubmed/19223628	Inhibitor 8504
Staphylococcus aureus growth 27 Target ID: Staphylococcus aureus growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/19223628	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Nutritional problems 1 Sources: https://www.drugs.com/pro/trophamine.html	Primary		Approved 8583	TrophAmine Approved Use TrophAmine is indicated for the nutritional support of infants (including those of low birth weight) and young pediatric patients requiring TPN via either central or peripheral infusion routes. Parenteral nutrition with TrophAmine is indicated to prevent nitrogen and weight loss or treat negative nitrogen balance in infants and young pediatric patients where (1) the alimentary tract, by the oral, gastrostomy, or jejunostomy route, cannot or should not be used, or adequate protein intake is not feasible by these routes; (2) gastrointestinal absorption of protein is impaired; or (3) protein requirements are substantially increased as with extensive burns. Launch Date 1984

C_max

Value	Dose	Co-administered	Analyte	Population
278 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2507878/	5 g single, intravenous dose: 5 g route of administration: Intravenous experiment type: SINGLE co-administered:		N-ACETYLTYROSINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Doses

Dose	Population	Adverse events
700 mg 3 times / day multiple, oral Higher than recommended Dose: 700 mg, 3 times / day Route: oral Route: multiple Dose: 700 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15187789/	unknown, ADULT Health Status: unknown Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/15187789/	Disc. AE: Metabolic disorder... AEs leading to discontinuation/dose reduction: Metabolic disorder (grade 2) Sources: https://pubmed.ncbi.nlm.nih.gov/15187789/

AEs

AE	Significance	Dose	Population
Metabolic disorder	grade 2 Disc. AE	700 mg 3 times / day multiple, oral Higher than recommended Dose: 700 mg, 3 times / day Route: oral Route: multiple Dose: 700 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15187789/	unknown, ADULT Health Status: unknown Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/15187789/

PubMed

Title	Date	PubMed
N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition.	2003-11-19	14621123

Patents

Sample Use Guides

In Vivo Use Guide

The best dosage range of NALT (N-Acetyltyrosine) is between 200-500 mgs per day. This can be taken all at once or spread throughout your day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:11:39 GMT 2025` Edited by `admin` on `Mon Mar 31 18:11:39 GMT 2025`
Record UNII	DA8G610ZO5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACETYL L-TYROSINE

Common Name

English

ACETYL TYROSINE

Preferred Name

English

N-ACETYLTYROSINE

Systematic Name

English

(+)-(2S)-2-(ACETYLAMINO)-3-(4-HYDROXYPHENYL)PROPANOIC ACID

Systematic Name

English

TYR-EXCEL

Brand Name

English

L-N-ACETYLTYROSINE

Common Name

English

N-ACETYLTYROSINE [EP MONOGRAPH]

Common Name

English

L-TYROSINE, N-ACETYL

Common Name

English

N-acetyltyrosin [WHO-DD]

Common Name

English

N-ACETYL-L-TYROSINE [USP-RS]

Common Name

English

N-ACETYLTYROSIN

Systematic Name

English

MELANOWHITE-A

Brand Name

English

(2S)-2-ACETYLAMINO-3-(4-HYDROXYPHENYL)PROPANOIC ACID

Systematic Name

English

N-ACETYL-L-TYROSINE

Systematic Name

English

TANOGEN HB

Brand Name

English

NSC-10853

Code

English

N-ACETYL-TYROSINE

Systematic Name

English

Classification Tree Code System Code

DSLD

3506 (Number of products:19)