Efparepoetin Alfa

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 14:50:08 GMT 2025` Edited by `admin` on `Wed Apr 02 14:50:08 GMT 2025`
Protein Type	FUSION PROTEINS
Protein Sub Type	IGG2
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	DA8DNU6AZ4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Efparepoetin Alfa

Common Name

English

Erythropoietin (human) fusion protein with peptide linker (GSGGG(SGGGG)2S) fusion protein with immunoglobulin G2 (recombinant human ?2-chain hinge-CH2-CH3 fragment)

Preferred Name

English

efparepoetin alfa [INN]

Common Name

English

human erythropoietin [R<sup>166</sup>>del]-variant (1-165 in the current sequence) fused via peptide linker<sup>166</sup> GSGGGSGGGGSGGGGS<sup>181</sup> to a Fc fragment of immunoglobulin G2 (182-407) [Homo sapiens IGHG1*01 (hinge N-terminal EPKSC delete

Common Name

English

Code System Code Type Description

SMS_ID

300000055869

Created by admin on Wed Apr 02 14:50:08 GMT 2025 , Edited by admin on Wed Apr 02 14:50:08 GMT 2025

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CAS

2761347-19-5

Created by admin on Wed Apr 02 14:50:08 GMT 2025 , Edited by admin on Wed Apr 02 14:50:08 GMT 2025

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FDA UNII

DA8DNU6AZ4

Created by admin on Wed Apr 02 14:50:08 GMT 2025 , Edited by admin on Wed Apr 02 14:50:08 GMT 2025

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INN

12856

Created by admin on Wed Apr 02 14:50:08 GMT 2025 , Edited by admin on Wed Apr 02 14:50:08 GMT 2025

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NCI_THESAURUS

C206905

Created by admin on Wed Apr 02 14:50:08 GMT 2025 , Edited by admin on Wed Apr 02 14:50:08 GMT 2025

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From	To
1_190	2_190
1_187	2_187
1_327	1_385
2_327	2_385
1_221	1_281
2_221	2_281
1_29	1_33
2_29	2_33
1_7	1_161
2_7	2_161

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_24
N	1_38
N	1_83
N	1_257
N	2_24
N	2_38
N	2_83
N	2_257
O	1_126
O	2_126

Related Record Type Details


					DA8DNU6AZ4

Efparepoetin Alfa

ACTIVE MOIETY

Comments:

antianaemic

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_407] [2_407]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
human erythropoietin fragment	PROTEIN FEATURE
Peptide linker	PROTEIN FEATURE
Fc fragment of immunoglobulin G2	PROTEIN FEATURE
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL