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Details

Stereochemistry RACEMIC
Molecular Formula C15H11I2O3.Na
Molecular Weight 516.0447
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENIODOL SODIUM

SMILES

[Na+].OC1=C(I)C=C(CC(C([O-])=O)C2=CC=CC=C2)C=C1I

InChI

InChIKey=JFFBJAOFKRCWPX-UHFFFAOYSA-M
InChI=1S/C15H12I2O3.Na/c16-12-7-9(8-13(17)14(12)18)6-11(15(19)20)10-4-2-1-3-5-10;/h1-5,7-8,11,18H,6H2,(H,19,20);/q;+1/p-1

HIDE SMILES / InChI
Molecular Formula C15H11I2O3
Molecular Weight 493.055
Charge -1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Iodoalphionic acid is the contrast medium, which was used for gallbladder examination. It is rarely appeared in the colon and, therefore, rarely masked the gallbladder. The density of the shadow produced by Iodoalphionic acid was greater than that produced by iodophthalein. It was reliable peroral cholecystographic medium, which was less objectionable to take and seldom causes vomiting. Diarrhoea occurred in some cases, but not more often than with tetraiodophenolphthalein. The ingestion of Iodoalphionic acid resulted in low thyroidal radioiodine accumulation for periods ranging from a few weeks to many months.

Originator

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8429
Biliselectan

Approved Use

It was used as a peroral cholecystographic agent
PubMed

PubMed

TitleDatePubMed
Pheniodol: A Contrast Medium for Cholecystography.
1943 Nov 27
Pheniodol, a new dye for cholecystography.
1946 Feb
Some experiences with priodax.
1946 Jun
Priodax and pseudoalbuminuria.
1950 Nov
Absorption and excretion of pheniodol.
1951 Jul 21
Comparison of cholecystography with iodoalphionic acid (priodax) and a new gallbladder dye, iodopropanoic acid (telepaque).
1952 Aug
[Inefficacy of iodoalphionic acid in radical cure of taeniasis].
1952 Nov-Dec
[Comparative cholecystographic study of iodopanoic acid (telepaque) and iodoalphionic acid].
1953
[Comparative study of iodopanoic acid (telepaque) and iodoalphionic acid (pheniodol) in cholecystography; densitometric and plainimetric x-ray study of 100 cases].
1954
[Duodenal intubation of acranil and iodoalphionic acid in therapy of teniasis].
1954 Jan-Mar
Cholegraphy; the new contrast medium biligrafin.
1955 May
Influence of iodoalphionic acid priodax, with and without thyrotropin, on thyroidal I 131 uptake in euthyroid patients.
1957 Jan
[A new mercurometric determination of pheniodol (Coletrast)].
1967 Aug
Unaltered bromsulphalein retention following cholecystography.
1968 Oct
[Effect of contrast agents on the iodine-absorbing function of the thyroid gland].
1982 Mar-Apr
[Effect of tri-iodine-containing x-ray contrast substances on the blood coagulation system in an experiment].
1984 Jul-Aug
[Competitive interrelations between bilirubin and x-ray contrast agents in binding with human serum albumin].
1986 Mar-Apr
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.
2004 May 6
Patents

Patents

GB 559024
2
US 2552696
2

Sample Use Guides

In Vivo Use Guide
4.2 g. suspended in water or milk
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:48:09 GMT 2023
Edited
by admin
on Fri Dec 15 15:48:09 GMT 2023
Record UNII
D3N32O7NLB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHENIODOL SODIUM
INN  
INN  
Official Name English
IODOALPHIONIC ACID, SODIUM SALT
Common Name English
PROPIONIC ACID, 3-(4-HYDROXY-3,5-DIIODOPHENYL)-2-PHENYL-, MONOSODIUM SALT
Common Name English
SODIUM IODOALPHIONATE
Common Name English
BENZENEPROPANOIC ACID, 4-HYDROXY-3,5-DIIODO-.ALPHA.-PHENYL-, MONOSODIUM SALT
Common Name English
SODIUM 3-(4-HYDROXY-3,5-DIIODOPHENYL)-2-PHENYLPROPIONATE
Systematic Name English
BENZENEPROPANOIC ACID, 4-HYDROXY-3,5-DIIODO-.ALPHA.-PHENYL-, SODIUM SALT (1:1)
Common Name English
pheniodol sodium [INN]
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL83906
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
DRUG CENTRAL
3303
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
NCI_THESAURUS
C175842
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
PUBCHEM
23665871
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
FDA UNII
D3N32O7NLB
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
SMS_ID
100000082236
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
EVMPD
SUB09766MIG
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
ECHA (EC/EINECS)
230-288-5
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
INN
4171
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
CAS
7009-60-1
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
Related Record Type Details
Structure of IODOALPHIONIC ACID
PARENT -> SALT/SOLVATE
NIH
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