IODOALPHIONIC ACID

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H12I2O3
Molecular Weight	494.0629
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0
Stereo Comments	DL-IODOALPHIONIC ACID

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C(CC1=CC(I)=C(O)C(I)=C1)C2=CC=CC=C2

InChI

InChIKey=IKYIXZSIKOYSLD-UHFFFAOYSA-N

InChI=1S/C15H12I2O3/c16-12-7-9(8-13(17)14(12)18)6-11(15(19)20)10-4-2-1-3-5-10/h1-5,7-8,11,18H,6H2,(H,19,20)

HIDE SMILES / InChI

Molecular Formula	C15H12I2O3
Molecular Weight	494.0629
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20987895 | https://www.ncbi.nlm.nih.gov/pubmed/20785145 | https://www.ncbi.nlm.nih.gov/pubmed/13385321

Iodoalphionic acid is the contrast medium, which was used for gallbladder examination. It is rarely appeared in the colon and, therefore, rarely masked the gallbladder. The density of the shadow produced by Iodoalphionic acid was greater than that produced by iodophthalein. It was reliable peroral cholecystographic medium, which was less objectionable to take and seldom causes vomiting. Diarrhoea occurred in some cases, but not more often than with tetraiodophenolphthalein. The ingestion of Iodoalphionic acid resulted in low thyroidal radioiodine accumulation for periods ranging from a few weeks to many months.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gallbladder disease 13 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20987895 https://www.ncbi.nlm.nih.gov/pubmed/20989933 https://www.ncbi.nlm.nih.gov/pubmed/20785145	Diagnostic		Approved 8429	Biliselectan Approved Use It was used as a peroral cholecystographic agent

PubMed

Title	Date	PubMed
Comparison of cholecystography with iodoalphionic acid (priodax) and a new gallbladder dye, iodopropanoic acid (telepaque).	1952 Aug	14948365
[Inefficacy of iodoalphionic acid in radical cure of taeniasis].	1952 Nov-Dec	13066283
[Comparative cholecystographic study of iodopanoic acid (telepaque) and iodoalphionic acid].	1953	13096516
[Duodenal intubation of acranil and iodoalphionic acid in therapy of teniasis].	1954 Jan-Mar	13189939
Effects of an organic iodine compound priodax on tests of thyroid function.	1957 Jan	13385320
[Effect of tri-iodine-containing x-ray contrast substances on the blood coagulation system in an experiment].	1984 Jul-Aug	6479314
[Competitive interrelations between bilirubin and x-ray contrast agents in binding with human serum albumin].	1986 Mar-Apr	3709775
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.	2004 May 6	15115392

Patents

Sample Use Guides

In Vivo Use Guide

4.2 g. suspended in water or milk

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:15:54 GMT 2023` Edited by `admin` on `Fri Dec 15 16:15:54 GMT 2023`
Record UNII	060B6580LL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOALPHIONIC ACID

Common Name

English

COLETRAST

Brand Name

English

TENAMID

Brand Name

English

.BETA.-(4-HYDROXY-3,5-DIIODOPHENYL)-.ALPHA.-PHENYLPROPIONIC ACID

Systematic Name

English

BILITRAST

Brand Name

English

BILISELKTAN

Brand Name

English

BISELECTAN

Brand Name

English

3-(4-HYDROXY-3,5-DIIODOPHENYL)-2-PHENYLPROPIONIC ACID

Systematic Name

English

DIKOL

Brand Name

English

PHENIODOL

Common Name

English

IODOALPHIONIC ACID [MI]

Common Name

English

NSC-404169

Code

English

BILIOGNOST

Brand Name

English

TENICID

Brand Name

English

JODOBIL

Brand Name

English

DL-IODOALPHIONIC ACID

Common Name

English

BILISELECTAN

Brand Name

English

IODOBIL

Brand Name

English

NSC-11854

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C28500