YM-26734

Details

Stereochemistry	MIXED
Molecular Formula	C45H62O8
Molecular Weight	730.969
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCC(=O)C1=C(O)C(C(=O)CCCCCCCCCCC)=C(O)C(C2CC(OC3=CC(O)=CC=C23)C4=CC=C(O)C=C4)=C1O

InChI

InChIKey=CEJAYJCUSZHYDS-UHFFFAOYSA-N

InChI=1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47)27-28-34(35)39/h23-29,35,38,46-47,50-52H,3-22,30H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C45H62O8
Molecular Weight	730.969
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Phospholipase A2, membrane associated 1 Target ID: P14555 Gene ID: 5320.0 Gene Symbol: PLA2G2A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8220906 \| https://www.ncbi.nlm.nih.gov/pubmed/8013541 \| https://www.ncbi.nlm.nih.gov/pubmed/14642775	Inhibitor 8297		1.0 µM [IC50]
Group IID secretory phospholipase A2 1 Target ID: Q9UNK4 Gene ID: 26279.0 Gene Symbol: PLA2G2D Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8220906 \| https://www.ncbi.nlm.nih.gov/pubmed/8013541 \| https://www.ncbi.nlm.nih.gov/pubmed/14642775	Inhibitor 8297		1.0 µM [IC50]

PubMed

Title	Date	PubMed
Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2.	1993 Sep	8220906

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:38:33 GMT 2023` Edited by `admin` on `Sat Dec 16 08:38:33 GMT 2023`
Record UNII	D27Z1V25BZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

YM-26734

Common Name

English

1-DODECANONE, 1,1'-(5-(3,4-DIHYDRO-7-HYDROXY-2-(4-HYDROXYPHENYL)-2H-1-BENZOPYRAN-4-YL)-2,4,6-TRIHYDROXY-1,3-PHENYLENE)BIS-

Systematic Name

English

1,1'-(5-(3,4-DIHYDRO-7-HYDROXY-2-(4-HYDROXYPHENYL)-2H-1-BENZOPYRAN-4-YL)-2,4,6-TRIHYDROXY-1,3-PHENYLENE)BIS(1-DODECANONE)

Systematic Name

English

Code System Code Type Description

FDA UNII

D27Z1V25BZ

Created by admin on Sat Dec 16 08:38:33 GMT 2023 , Edited by admin on Sat Dec 16 08:38:33 GMT 2023

PRIMARY

PUBCHEM

9853400

Created by admin on Sat Dec 16 08:38:33 GMT 2023 , Edited by admin on Sat Dec 16 08:38:33 GMT 2023

PRIMARY

EPA CompTox

DTXSID20932293

Created by admin on Sat Dec 16 08:38:33 GMT 2023 , Edited by admin on Sat Dec 16 08:38:33 GMT 2023

PRIMARY

CAS

144337-18-8

Created by admin on Sat Dec 16 08:38:33 GMT 2023 , Edited by admin on Sat Dec 16 08:38:33 GMT 2023

PRIMARY

Related Record Type Details


					D27Z1V25BZ

YM-26734

ACTIVE MOIETY