TENILAPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16N4S2
Molecular Weight	340.466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)C2=NC3=CSC=C3\C(=C\C#N)C4=CSC=C24

InChI

InChIKey=RVQVUMIXBGFJLZ-SWGQDTFXSA-N

InChI=1S/C17H16N4S2/c1-20-4-6-21(7-5-20)17-15-10-22-8-13(15)12(2-3-18)14-9-23-11-16(14)19-17/h2,8-11H,4-7H2,1H3/b12-2+

HIDE SMILES / InChI

Molecular Formula	C17H16N4S2
Molecular Weight	340.466
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10991983 | https://www.ncbi.nlm.nih.gov/pubmed/8524985

Tenilapine is an atypical antipsychotic drug that acts as a potent inverse agonist at 5-HT(2C) receptor. In addition, tenilapine has relatively low affinities for the D4 receptor. Information about the current application of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells.	1992 Feb	1346637
Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.	1992 Mar	1347569
D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs.	1995 Aug	8524985
Muscarinic m4 receptor activation by some atypical antipsychotic drugs.	1997 Mar 5	9085047

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:50:55 UTC 2023` Edited by `admin` on `Fri Dec 15 15:50:55 UTC 2023`
Record UNII	D0U312O2BE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TENILAPINE

Official Name

English

tenilapine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710