EFLOXATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H16O5
Molecular Weight	324.3273
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)COC1=CC2=C(C=C1)C(=O)C=C(O2)C3=CC=CC=C3

InChI

InChIKey=ZVXBAHLOGZCFTP-UHFFFAOYSA-N

InChI=1S/C19H16O5/c1-2-22-19(21)12-23-14-8-9-15-16(20)11-17(24-18(15)10-14)13-6-4-3-5-7-13/h3-11H,2,12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H16O5
Molecular Weight	324.3273
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/13816307
Curator's Comment: description was created based on several sources, including, http://www.recordati.com/en/about_us/history/

Efloxate is a coronary vasodilator developed in 1959 in Italy by Recordati and used for the treatment of angina pectoris. The drug is no longer marketed.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Angina pectoris 106 Sources: http://www.ncbi.nlm.nih.gov/pubmed/13816307	Primary		Approved 8429	RECORDIL Approved Use Unknown

PubMed

Title	Date	PubMed
[Ethyl-7-hydroxyaceto-flavone (recordil) in the therapy of angina pectoris and its effects on hemodynamics and renal function].	1959	13629509
A clinical trial of penta-erythritol tetranitrate, a khellin derivative (recordil), and iproniazid in angina of effort.	1959 Jul	13816307
[Clinical research on the therapeutic efficacy and tolerance of long-acting efloxate in angina pectoris].	1977 Aug 15	334448
[The effect of 4'-methylrecordil on coronary artery blood flow and experimental myocardial infarction in rabbits].	1982 Jul	7180478
[Mutagenesis of efloxate tested in vitro and in vivo].	1985 Mar	3896262

Sample Use Guides

In Vivo Use Guide

One 15 mg. tablet a day, gradually increased over 7 to 8 days to 3 or 4 tablets daily (45 to 60 mg.), and given over a period of at least three months.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:14:35 UTC 2023` Edited by `admin` on `Fri Dec 15 16:14:35 UTC 2023`
Record UNII	CZU6V3902K
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EFLOXATE

Official Name

English

EFLOXATE [JAN]

Common Name

English

ETHYL-((4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL)OXY) ACETATE

Systematic Name

English

Efloxate [WHO-DD]

Common Name

English

efloxate [INN]

Common Name

English

NSC-758891

Code

English

EFLOXATE [MI]

Common Name

English

EFLOXATE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29707