AZD-1305

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H31FN4O4
Molecular Weight	434.5043
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)OC(=O)NCCN1C[C@H]2CN(CCOC3=C(F)C=C(C=C3)C#N)C[C@@H](C1)O2

InChI

InChIKey=BLLNYXOLLAVTRF-HDICACEKSA-N

InChI=1S/C22H31FN4O4/c1-22(2,3)31-21(28)25-6-7-26-12-17-14-27(15-18(13-26)30-17)8-9-29-20-5-4-16(11-24)10-19(20)23/h4-5,10,17-18H,6-9,12-15H2,1-3H3,(H,25,28)/t17-,18+

HIDE SMILES / InChI

Molecular Formula	C22H31FN4O4
Molecular Weight	434.5043
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21561900 | https://clinicaltrials.gov/ct2/show/NCT00748982 | https://clinicaltrials.gov/ct2/show/NCT00915356

AZD1305, an antiarrhythmic agent, blocks the hERG potassium channel, the L-type calcium, and the Sodium channel protein Nav1.5. AZD1305 participated in clinical trials for the management of atrial fibrillation and Left ventricular dysfunction. The benefit-risk profile was judged as unfavorable and the AZD1305 development programme was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

AZD1305 (tablet) loading dose 250 mg + 125 mg evening dose on Study Day 1, maintenance dose 125 mg twice daily from Study Day 2 iv single infusion: initial iv loading dose which will be followed by a maintenance dose given for a maximum of 90 minutes

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:48:54 GMT 2023` Edited by `admin` on `Fri Dec 15 19:48:54 GMT 2023`
Record UNII	CZO834LXQM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZD-1305

Common Name

English

AZD1305

Common Name

English

CARBAMIC ACID, (2-(7-(2-(4-CYANO-2-FLUOROPHENOXY)ETHYL)-9-OXA-3,7-DIAZABICYCLO(3.3.1)NON-3-YL)ETHYL)-, 1,1-DIMETHYLETHYL ESTER

Common Name

English

AZD 1305 [WHO-DD]

Common Name

English

(2-(7-(2-(4-CYANO-2-FLUOROPHENOXY)ETHYL)-9-OXA-3,7-DIAZABICYCLO(3.3.1)NON-3-YL)ETHYL)CARBAMIC ACID TERT-BUTYL ESTER

Systematic Name

English

TERT-BUTYL (2-(7-(2-(4-CYANO-2-FLUOROPHENOXY)ETHYL)-9-OXA-3,7-DIAZABICYCLO(3.3.1)NON-3-YL)ETHYL)CARBAMATE

Systematic Name

English

Code System Code Type Description

ChEMBL

CHEMBL3545169