RWJ-800088

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:26:55 GMT 2025` Edited by `admin` on `Tue Apr 01 23:26:55 GMT 2025`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	CU0FSR29BQ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RWJ-800088

Common Name

English

GW-395058

Preferred Name

English

RWJ-800088 (PEGYLATED THROMBOPOIETIN (TPO)-MIMETIC PEPTIDE)

Common Name

English

METHOXYPOLYETHYLENEGLYCOL20000-PROPIONYL-L-ISOLEUCYL-L-GLUTAMYL-GLYCYL-L-PROLYL-L-THREONYL-L-LEUCYL-L-ARGINYL-L-GLUTAMINYL-L-2-NAPHTHYLALANYL-L-LEUCYL-L-ALANYL-L-ALANYL-L-ARGINYLSARCOSYL-NE-(METHOXYPOLYETHYLENEGLYCOL20000-PROPIONYL-L-ISOLEUCYL-L-GLUTAMYL

Systematic Name

English

SF003

Code

English

JNJ-26366821

Code

English

a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology to endogenous

Common Name

English

POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-HYDRO-.OMEGA.-METHOXY-, 1,1'-DIETHER WITH N2,N6-BIS(N-(3-HYDROXY-1-OXOPROPYL)-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-PROLYL-L-THREONYL-L-LEUCYL-L-ARGINYL-L-GLUTAMINYL-3-(2-NAPHTHALENYL)-L-ALANYL-L-LEUCYL-L-ALANYL-L-ALANY

Systematic Name

English

SF-003

Code

English

JNJ26366821

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

878222

Created by admin on Tue Apr 01 23:26:55 GMT 2025 , Edited by admin on Tue Apr 01 23:26:55 GMT 2025

FDA ORPHAN DRUG

878122

Created by admin on Tue Apr 01 23:26:55 GMT 2025 , Edited by admin on Tue Apr 01 23:26:55 GMT 2025

Code System Code Type Description

CAS

257287-15-3

Created by admin on Tue Apr 01 23:26:55 GMT 2025 , Edited by admin on Tue Apr 01 23:26:55 GMT 2025

PRIMARY

FDA UNII

CU0FSR29BQ

Created by admin on Tue Apr 01 23:26:55 GMT 2025 , Edited by admin on Tue Apr 01 23:26:55 GMT 2025

PRIMARY

Linkage Type	Residue Index
AMIDE BOND	1_13	2_13

Related Record Type Details


					UUX6AY249E

THROMBOPOIETIN RECEPTOR

TARGET -> AGONIST

Amount:

Related Record Type Details


					CU0FSR29BQ

RWJ-800088

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_9] [2_9]	SITE_SPECIFIC	2-NAPHTHYLALANINE	W425Q6KV9R
AMINO_ACID_SUBSTITUTION	[1_13] [2_13]	SITE_SPECIFIC	ARGINYL-SARCOSYL-LYSYL-SARCOSYL-ARGINYL CROSSLINKER	QGC6XD9T99
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	SITE_SPECIFIC	MPEG-ISOLEUCINE (20000 MW)	4KTY094UYK

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL