U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 23:26:55 GMT 2025
Edited
by admin
on Tue Apr 01 23:26:55 GMT 2025
Protein Type PEPTIDE
Protein Sub Type
Sequence Type COMPLETE
Record UNII
CU0FSR29BQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RWJ-800088
Common Name English
GW-395058
Preferred Name English
RWJ-800088 (PEGYLATED THROMBOPOIETIN (TPO)-MIMETIC PEPTIDE)
Common Name English
METHOXYPOLYETHYLENEGLYCOL20000-PROPIONYL-L-ISOLEUCYL-L-GLUTAMYL-GLYCYL-L-PROLYL-L-THREONYL-L-LEUCYL-L-ARGINYL-L-GLUTAMINYL-L-2-NAPHTHYLALANYL-L-LEUCYL-L-ALANYL-L-ALANYL-L-ARGINYLSARCOSYL-NE-(METHOXYPOLYETHYLENEGLYCOL20000-PROPIONYL-L-ISOLEUCYL-L-GLUTAMYL
Systematic Name English
SF003
Code English
JNJ-26366821
Code English
a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology to endogenous
Common Name English
POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-HYDRO-.OMEGA.-METHOXY-, 1,1'-DIETHER WITH N2,N6-BIS(N-(3-HYDROXY-1-OXOPROPYL)-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-PROLYL-L-THREONYL-L-LEUCYL-L-ARGINYL-L-GLUTAMINYL-3-(2-NAPHTHALENYL)-L-ALANYL-L-LEUCYL-L-ALANYL-L-ALANY
Systematic Name English
SF-003
Code English
JNJ26366821
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 878222
Created by admin on Tue Apr 01 23:26:55 GMT 2025 , Edited by admin on Tue Apr 01 23:26:55 GMT 2025
FDA ORPHAN DRUG 878122
Created by admin on Tue Apr 01 23:26:55 GMT 2025 , Edited by admin on Tue Apr 01 23:26:55 GMT 2025
Code System Code Type Description
CAS
257287-15-3
Created by admin on Tue Apr 01 23:26:55 GMT 2025 , Edited by admin on Tue Apr 01 23:26:55 GMT 2025
PRIMARY
FDA UNII
CU0FSR29BQ
Created by admin on Tue Apr 01 23:26:55 GMT 2025 , Edited by admin on Tue Apr 01 23:26:55 GMT 2025
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_9] [2_9] SITE_SPECIFIC 2-NAPHTHYLALANINE W425Q6KV9R
AMINO_ACID_SUBSTITUTION [1_13] [2_13] SITE_SPECIFIC ARGINYL-SARCOSYL-LYSYL-SARCOSYL-ARGINYL CROSSLINKER QGC6XD9T99
AMINO_ACID_SUBSTITUTION [1_1] [2_1] SITE_SPECIFIC MPEG-ISOLEUCINE (20000 MW) 4KTY094UYK
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE CHEMICAL