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Details

Stereochemistry ACHIRAL
Molecular Formula CCl4
Molecular Weight 153.823
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Carbon tetrachloride

SMILES

ClC(Cl)(Cl)Cl

InChI

InChIKey=VZGDMQKNWNREIO-UHFFFAOYSA-N
InChI=1S/CCl4/c2-1(3,4)5

HIDE SMILES / InChI

Molecular Formula CCl4
Molecular Weight 153.823
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Carbon tetrachloride, also called tetrachloromethane, a colourless, dense, highly toxic, volatile, nonflammable liquid possessing a characteristic odour and belonging to the family of organic halogen compounds, used principally in the manufacture of dichlorodifluoromethane. Carbon tetrachloride is commonly used as a chemical intermediate, solvent, and dry-cleaning fluid. It was widely used as a cleaning fluid. Carbon tetrachloride was also used in fire extinguishers and as a fumigant to kill insects in grain. Human exposure to carbon tetrachloride from occupational or environmental sources is low and unlikely to produce acute kidney toxicity. Carbon tetrachloride is a manufactured chemical and does not occur naturally in the environment.

Approval Year

PubMed

PubMed

TitleDatePubMed
Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL.
2001-07-13
Investigation of cell exudates active in carbon tetrachloride and chloroform degradation.
2001-07-05
Hepatoprotective activity of Luffa echinata fruits.
2001-07
JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells.
2001-06-29
Time-resolved total internal reflection fluorometry study on polarity at a liquid/liquid interface.
2001-06-01
Kinetics and mechanisms of hepatic acute phase response to subtotal partial hepatectomy and cultural impact on environmental hepatic end-stage liver injury in the homeless.
2001-06
Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury.
2001-06
Influence of ferrous iron and ph on carbon tetrachloride degradation by Methanosarcina thermophila.
2001-06
Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants.
2001-06
Hepatocyte growth factor promotes liver regeneration and protein synthesis after hepatectomy in cirrhotic rats.
2001-05-31
Hepatocyte damage induced by carbon tetrachloride: inhibited lipoprotein secretion and changed lipoprotein composition.
2001-05-24
Radiolytic and thermal dechlorination of organic chlorides adsorbed on molecular sieve 13X.
2001-05-15
Visualization of solute migration in chromatographic columns influence of the frit porosity.
2001-05-11
Noninvasive determination of the location and distribution of DNAPL using advanced seismic reflection techniques.
2001-05-09
Risk of pancreatic cancer in workers exposed to chlorinated hydrocarbon solvents and related compounds: a meta-analysis.
2001-05-01
Rhamnazin-4'-O-beta-[apiosyl(1-->2)] glucoside as a means of antioxidative defense against tetrachloromethane induced hepatotoxicity in rats.
2001-05
The influence of chlorine on the intensity of metal atomic lines emitted by an electrolyte cathode atmospheric glow discharge.
2001-05
Determination of elemental sulfur in coal by gas chromatography-mass spectrometry.
2001-05
Transplantation of cultured allogeneic hepatocytes without immunosuppression.
2001-05
Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.
2001-05
Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.
2001-05
RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays.
2001-05
Liver-type arginase is a highly sensitive marker for hepatocellular damage in rats.
2001-05
Role of nitric oxide (NO) in pulmonary dysfunction associated with experimental cirrhosis.
2001-05
Analysis of C2-C4 peroxyacyl nitrates and C1-C5 alkyl nitrates with a non-polar capillary column.
2001-04-27
Pathogenesis of carbon tetrachloride-induced hepatocyte injury bioactivation of CCI4 by cytochrome P450 and effects on lipid homeostasis.
2001-04-17
Prooxidant and antioxidant functions of nitric oxide in liver toxicity.
2001-04
Increase of tissue lipid hydroperoxides as determination of oxidative stress.
2001-04
Glycogen-forming function of hepatocytes in cirrhotically altered rat liver after treatment with chorionic gonadotropin.
2001-04
Carbon tetrachloride-induced acute liver injury in Mini and Wistar rats.
2001-04
Protective effects of acetylbergenin against carbon tetrachloride-induced hepatotoxicity in rats.
2001-04
Reduction of carbon tetrachloride-induced rat liver injury by IRFI 042, a novel dual vitamin E-like antioxidant.
2001-04
Enhanced expression of endothelin receptor subtypes in cirrhotic rat liver.
2001-04
Regulation of cholangiocyte proliferation.
2001-04
Measurement of volatile organic compounds in sediments of the Scheldt estuary and the Southern North Sea.
2001-04
Role of inflammation in chemical-induced hepatotoxicity.
2001-03-31
Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?
2001-03-31
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis.
2001-03-31
Apoptosis in dissociation between DNA synthesis and cellular functions of activated hepatic stellate cells--a study with carbon tetrachloride-induced rat liver injury.
2001-03-30
Visible light-induced degradation of carbon tetrachloride on dye-sensitized TiO2.
2001-03-01
5'-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication.
2001-03
Efficiency of rice bran for removal of organochlorine compounds and benzene from industrial wastewater.
2001-03
Transformation of chlorinated aliphatic compounds by ferruginous smectite.
2001-02-15
Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver.
2001-02-14
Carbon tetrachloride dechlorination by the bacterial transition metal chelator pyridine-2,6-bis(thiocarboxylic acid).
2001-02-01
The role of antioxidant vitamins (C and E), selenium and Nigella sativa in the prevention of liver fibrosis and cirrhosis in rabbits: new hopes.
2001-02
Vitamin E reduces lipid peroxidation in experimental hepatotoxicity in rats.
2001-02
Fructose, 1,6-diphosphate mitigates CCl4 suppressed nitric oxide synthase activity in rats.
2001-01
Interaction between monensin and CCl4 after chronic treatment: dolichol and retinol content of rat liver sinusoidal cells.
2001
Applications of microarray technology in breast cancer research.
2001
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:32:11 GMT 2025
Edited
by admin
on Mon Mar 31 18:32:11 GMT 2025
Record UNII
CL2T97X0V0
Record Status Validated (UNII)
Record Version
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Name Type Language
Carbon tetrachloride
HSDB   ISO   MART.   MI   WHO-DD  
Systematic Name English
CARBONEUM CHLORATUM
HPUS  
Preferred Name English
CARBONEUM CHLORATUM [HPUS]
Common Name English
CARBON TETRACHLORIDE [IARC]
Common Name English
CARBON TETRACHLORIDE [MI]
Common Name English
METHANE, TETRACHLORO-
Systematic Name English
CARBON TETRACHLORIDE [USP-RS]
Common Name English
CARBON TETRACHLORIDE [MART.]
Common Name English
Carbon tetrachloride [WHO-DD]
Common Name English
CARBON TETRACHLORIDE [ISO]
Common Name English
CARBON TETRACHLORIDE [HSDB]
Common Name English
NSC-97063
Code English
Classification Tree Code System Code
IARC Carbon tetrachloride
EPA PESTICIDE CODE 16501
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
NCI_THESAURUS C45386
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
Code System Code Type Description
FDA UNII
CL2T97X0V0
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
MESH
D002251
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PRIMARY
RXCUI
2383337
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PRIMARY
CAS
56-23-5
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PRIMARY
DAILYMED
CL2T97X0V0
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
ALANWOOD
carbon tetrachloride
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PRIMARY
SMS_ID
300000053205
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PRIMARY
HSDB
52
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PRIMARY
ChEMBL
CHEMBL44814
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
DRUG CENTRAL
3067
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PRIMARY
RS_ITEM_NUM
1601168
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
WIKIPEDIA
CARBON TETRACHLORIDE
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
EPA CompTox
DTXSID8020250
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
PUBCHEM
5943
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PRIMARY
ECHA (EC/EINECS)
200-262-8
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PRIMARY
NSC
97063
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
CHEBI
27385
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
NCI_THESAURUS
C44350
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY
MERCK INDEX
m3086
Created by admin on Mon Mar 31 18:32:11 GMT 2025 , Edited by admin on Mon Mar 31 18:32:11 GMT 2025
PRIMARY Merck Index