SAFIRONIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H23N3O4
Molecular Weight	309.3608
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCCCNC(=O)C1=CC(=NC=C1)C(=O)NCCCOC

InChI

InChIKey=HLSXICGBWKECLM-UHFFFAOYSA-N

InChI=1S/C15H23N3O4/c1-21-9-3-6-17-14(19)12-5-8-16-13(11-12)15(20)18-7-4-10-22-2/h5,8,11H,3-4,6-7,9-10H2,1-2H3,(H,17,19)(H,18,20)

HIDE SMILES / InChI

Molecular Formula	C15H23N3O4
Molecular Weight	309.3608
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9422545 | https://adisinsight.springer.com/drugs/800007377

Aventis developed safironil as a competitive inhibitor of collagen protein synthesis for the treatment of liver disorders. This compound participated in phase I clinical trial for the treatment of cirrhosis in Germany. In addition, it was studied for hepatic fibrosis treatment. However, information about the further development of this compound is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females.	1998 Jan	9422545

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:04:47 GMT 2023` Edited by `admin` on `Sat Dec 16 17:04:47 GMT 2023`
Record UNII	CK4M8AX1LN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SAFIRONIL

Official Name

English

safironil [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471