Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H17NO4 |
| Molecular Weight | 383.3961 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1)C2=C(C(=O)C3=CC=C(C=C3)C#N)C4=CC=C(OC)C=C4O2
InChI
InChIKey=RYNSGDFWBJWWSZ-UHFFFAOYSA-N
InChI=1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3
| Molecular Formula | C24H17NO4 |
| Molecular Weight | 383.3961 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
LY-320135 is a substituted benzofuran which is structurally
distinct from the aminoalkylindole and pyrazole type
cannabinoid antagonists, AM630 and SR141716A, respectively. LY-320135 is a potent and selective canniboid CB1 receptor antagonist/inverse agonist. LY-320135 is selective (~70 fold) over canniboid CB2 receptors. LY-320135 is widely used in research, particularly for elucidating the mechanisms by which many CB1 antagonists act as inverse agonists at higher doses. LY-320135 shows weak binding to both 5-HT2 (Ki = 6.4 uM) and muscarinic receptors (Ki = 2.1 uM).
CNS Activity
Approval Year
Sample Use Guides
Rats: pretreatment of rats with 6 mg/kg, i.v., LY-320135 resulted in reduction in infarct volume compared with vehicle treated rats.
Route of Administration:
Intravenous
In Vitro Use Guide
Curator's Comment: LY-320135 was neuroprotective with maximal activity at 1 uM in rat organotypic hippocampal slices exposed to 20 min oxygen-glucose deprivation (OGD) https://www.ncbi.nlm.nih.gov/pubmed/21130785
LY-320135 blocked the anandamide + forskolin-mediated
stimulation of cAMP accumulation with IC50 value of 734 nM in pertussis toxin-treated CHO-CB1 cells..
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:30:55 UTC 2023
by
admin
on
Sat Dec 16 08:30:55 UTC 2023
|
| Record UNII |
CJY03984CT
|
| Record Status |
Validated (UNII)
|
| Record Version |
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176977-56-3
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5311257
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CJY03984CT
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DTXSID901027464
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LY-320,135
Created by
admin on Sat Dec 16 08:30:55 UTC 2023 , Edited by admin on Sat Dec 16 08:30:55 UTC 2023
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ACTIVE MOIETY |
