OP-145

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 18:42:15 GMT 2023` Edited by `admin` on `Sat Dec 16 18:42:15 GMT 2023`
Protein Type	PEPTIDE
Protein Sub Type	ANTIBACTERIAL PEPTIDE
Sequence Type	COMPLETE
Record UNII	CFU4G4GMY9
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OP-145

Common Name

English

P60.4AC

Code

English

(4S)-4-(((2S)-2-((2-(((2S,3S)-2-ACETAMIDO-3-METHYL-PENTANOYL)AMINO)ACETYL)AMINO)-6-AMINO-HEXANOYL)AMINO)-5-(((1S)-2-(((1S)-5-AMINO-1-(((1S)-1-(((1S,2S)-1-(((1S)-1-(((1S)-1-(((1S)-1-(((1S,2S)-1-(((1S)-5-AMINO-1-(((1S)-1-(((1S)-1-BENZYL-2-(((1S)-1-(((1S)-1

Systematic Name

English

L-ARGININE, L-ISOLEUCYLGLYCYL-L-LYSYL-L-.ALPHA.-GLUTAMYL-L-PHENYLALANYL-L-LYSYL-L-ARGINYL-L-ISOLEUCYL-L-VALYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-ISOLEUCYL-L-LYSYL-L-ARGINYL-L-PHENYLALANYL-L-LEUCYL-L-ARGINYL-L-.ALPHA.-GLUTAMYL-L-LEUCYL-L-VALYL-L-ARGINYL-L-PRO

Systematic Name

English

Code System Code Type Description

CAS

732984-79-1

Created by admin on Sat Dec 16 18:42:15 GMT 2023 , Edited by admin on Sat Dec 16 18:42:15 GMT 2023

PRIMARY

FDA UNII

CFU4G4GMY9

Created by admin on Sat Dec 16 18:42:15 GMT 2023 , Edited by admin on Sat Dec 16 18:42:15 GMT 2023

PRIMARY

Related Record Type Details


					CFU4G4GMY9

OP-145

ACTIVE MOIETY

Comments:

Killing of MRSA by P60.4Ac in the two creams was less effective than in hypromellose. In agreement, P60.4Ac in hypromellose was highly effective in eradicating the two MRSA strains from EMs. We found that already 0.1% (wt/wt) P60.4Ac in hypromellose gel killed >99% of the viable planktonic bacteria and >85% of biofilm-associated-bacteria on EMs. Hypromellose gels containing 0.1% and 0.5% (wt/wt) P60.4Ac effectively reduced the numbers of viable MRSA by >90% from BEMs. No cytotoxic effects of P60.4Ac in hypromellose up to 2% on keratinocytes in EMs and up to 0.5% (wt/wt) on epithelial cells in BEMs were observed. HPLC analysis showed that P60.4Ac was stable in softisan cream and hypromellose gel, but not in cetomacrogol cream. We conclude that P60.4Ac formulated in hypromellose gel is both stable and highly effective in eradicating MRSA from colonized EMs and BEMs.

Amount:


					CFU4G4GMY9

OP-145

ACTIVE MOIETY

Comments:

Class: Peptide antibiotic; Mechanism of Action: Immunostimulant; Highest Development Phase: Discontinued for Otitis media; Most Recent Events: 27 Feb 2013 OctoPlus has been acquired by Dr Reddys Laboratories, 30 Nov 2010 OP 145 is available for licensing as of 30 Nov 2010. http://www.octoplus.nl, 15 Sep 2009 Efficacy & adverse events data from a phase II trial in Otitis media presented at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC-2009)

Amount:


					CFU4G4GMY9

OP-145

ACTIVE MOIETY

Comments:

Background and study aims: Chronic suppurative otitis media (CSOM) is a long-lasting infection of the middle ear. The middle ear, also known as the tympanic cavity, is the name given to the air-filled space directly behind the ear drum. In CSOM, an infection leads to long-lasting irritation of this area causing pus to continually drain from the ear (suppuration) and even hearing loss in the affected ear. The first line treatment for CSOM is the use of antibiotics, which work to fight the infection. When antibiotics are used a lot, bacteria can become resistant to their effects, which make them much more difficult to treat. OP-145 is a new product which has been shown to be effective against harmful microorganisms and to reduce inflammation. The aim of this study is to find out whether OP-145-containing ear drops are an effective and safe treatment for CSOM in adults.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL