Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H20N2O4 |
| Molecular Weight | 340.3731 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC1(O)C(=O)N(N(C1=O)C2=CC=C(O)C=C2)C3=CC=CC=C3
InChI
InChIKey=DPLOKDYHDJEJST-UHFFFAOYSA-N
InChI=1S/C19H20N2O4/c1-2-3-13-19(25)17(23)20(14-7-5-4-6-8-14)21(18(19)24)15-9-11-16(22)12-10-15/h4-12,22,25H,2-3,13H2,1H3
| Molecular Formula | C19H20N2O4 |
| Molecular Weight | 340.3731 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:32:26 GMT 2023
by
admin
on
Sat Dec 16 11:32:26 GMT 2023
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| Record UNII |
CE22DLC7GR
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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Code | English |
| Code System | Code | Type | Description | ||
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9798014
Created by
admin on Sat Dec 16 11:32:26 GMT 2023 , Edited by admin on Sat Dec 16 11:32:26 GMT 2023
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55648-39-0
Created by
admin on Sat Dec 16 11:32:26 GMT 2023 , Edited by admin on Sat Dec 16 11:32:26 GMT 2023
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PRIMARY | |||
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CE22DLC7GR
Created by
admin on Sat Dec 16 11:32:26 GMT 2023 , Edited by admin on Sat Dec 16 11:32:26 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
4-Hydroxy-oxyphenbutazone (4OH-OPB), is currently in phase II trials for its immunosuppressive effect in patients with rheumatoid arthritis. 4OH-OPB and other compounds related to phenylbutazone were tested for their effect on in vitro cytokine production by monocytes and lymphocytes present in peripheral mononuclear cells (PBMC) or whole blood (WB) cultures, and compared against phenylbutazone and oxyphenbutazone, two known anti-inflammatory drugs. In PBMC cultures, 4OH-OPB was by far the most potent inhibitor, and both monokines and Th1 and Th2 lymphokines were efficiently inhibited at low concentrations.
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