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Details

Stereochemistry ACHIRAL
Molecular Formula C15H20N2O4
Molecular Weight 292.3303
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FILAMINAST

SMILES

COC1=CC=C(C=C1OC2CCCC2)C(\C)=N\OC(N)=O

InChI

InChIKey=STTRYQAGHGJXJJ-LICLKQGHSA-N
InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)/b17-10+

HIDE SMILES / InChI
Molecular Formula C15H20N2O4
Molecular Weight 292.3303
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

FILAMINAST is a phosphodiesterase 4 inhibitor with bronchorelaxant activity and selectivity of potential use in the treatment of asthma. However, its clinical development was discontinued due to lack of efficacy.

Originator

Wyeth
116

Approval Year

Unknown
139,594

PubMed

Patents

JP2003506394A
4
JP4532115B2
9

Sample Use Guides

In Vitro Use Guide
FILAMINAST was identified as a preferential inhibitor of phosphodiesterase (PDE) 4, possessing 36 times greater potency versus canine trachealis PDE4 than PDE3 (IC50, 4.2*10^-7 M and 1.5*10^-5 M, respectively).
Substance Class Chemical
Record UNII
CDD69JC61J
Record Status Validated (UNII)
Record Version
NIH
NCATS
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