FOXY-5

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H42N6O12S2
Molecular Weight	694.775
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSCC[C@H](NC=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

InChIKey=WFZPJYYCTSHDJI-ATIWLJMLSA-N

InChI=1S/C26H42N6O12S2/c1-13(2)8-17(26(43)44)32-24(41)15(4-5-20(35)36)30-25(42)18(11-45)29-19(34)10-27-22(39)16(9-21(37)38)31-23(40)14(28-12-33)6-7-46-3/h12-18,45H,4-11H2,1-3H3,(H,27,39)(H,28,33)(H,29,34)(H,30,42)(H,31,40)(H,32,41)(H,35,36)(H,37,38)(H,43,44)/t14-,15-,16-,17-,18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C26H42N6O12S2
Molecular Weight	694.775
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28886116 | https://clinicaltrials.gov/ct2/show/NCT03883802 |

Foxy-5, a wingless-type mammary tumor virus integration site 5A (WNT5A)-mimicking peptide, was studied for the treatment of cancer. Foxy-5 is participating in phase II clinical trial as neo-adjuvant therapy for the treatment of patients with wnt-5a low colon cancer. Besides, Foxy-5 was used in phase I clinical trial, for the treatment of prostate cancer patients with tumors exhibiting absent or low WNT5A expression.

Originator

Approval Year

PubMed

Title	Date	PubMed
The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility.	2008 Oct 15	18927296
Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.	2017	28886116
WNT5A as a therapeutic target in breast cancer.	2018 Dec	30171384
The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer.	2019 Apr	30952711

Sample Use Guides

In Vivo Use Guide

Lyophilized powder for solution for intravenous infusion

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:17:42 GMT 2023` Edited by `admin` on `Sat Dec 16 04:17:42 GMT 2023`
Record UNII	CBZ9UL0ARB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOXY-5

Common Name

English

FOXY5

Common Name

English

WNT-5A DERIVED HEXAPEPTIDE FOXY-5

Common Name

English

N-FORMYL-MET-ASP-GLY-CYS-GLU-LEU

Common Name

English

L-LEUCINE, N-FORMYL-L-METHIONYL-L-.ALPHA.-ASPARTYLGLYCYL-L-CYSTEINYL-L-.ALPHA.-GLUTAMYL-

Systematic Name

English

FOXY 5 [WHO-DD]

Common Name

English

Code System Code Type Description

EVMPD

SUB193858