FOXY-5

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H42N6O12S2
Molecular Weight	694.775
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSCC[C@H](NC=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

InChIKey=WFZPJYYCTSHDJI-ATIWLJMLSA-N

InChI=1S/C26H42N6O12S2/c1-13(2)8-17(26(43)44)32-24(41)15(4-5-20(35)36)30-25(42)18(11-45)29-19(34)10-27-22(39)16(9-21(37)38)31-23(40)14(28-12-33)6-7-46-3/h12-18,45H,4-11H2,1-3H3,(H,27,39)(H,28,33)(H,29,34)(H,30,42)(H,31,40)(H,32,41)(H,35,36)(H,37,38)(H,43,44)/t14-,15-,16-,17-,18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C26H42N6O12S2
Molecular Weight	694.775
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28886116 | https://clinicaltrials.gov/ct2/show/NCT03883802 |

Foxy-5, a wingless-type mammary tumor virus integration site 5A (WNT5A)-mimicking peptide, was studied for the treatment of cancer. Foxy-5 is participating in phase II clinical trial as neo-adjuvant therapy for the treatment of patients with wnt-5a low colon cancer. Besides, Foxy-5 was used in phase I clinical trial, for the treatment of prostate cancer patients with tumors exhibiting absent or low WNT5A expression.

Originator

Approval Year

PubMed

Title	Date	PubMed
The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer.	2019-04	30952711
WNT5A as a therapeutic target in breast cancer.	2018-12	30171384
Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.	2017	28886116
The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility.	2008-10-15	18927296

Sample Use Guides

In Vivo Use Guide

Lyophilized powder for solution for intravenous infusion

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:21:27 GMT 2025` Edited by `admin` on `Mon Mar 31 21:21:27 GMT 2025`
Record UNII	CBZ9UL0ARB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOXY-5

Common Name

English

FOXY5

Preferred Name

English

WNT-5A DERIVED HEXAPEPTIDE FOXY-5

Common Name

English

N-FORMYL-MET-ASP-GLY-CYS-GLU-LEU

Common Name

English

L-LEUCINE, N-FORMYL-L-METHIONYL-L-.ALPHA.-ASPARTYLGLYCYL-L-CYSTEINYL-L-.ALPHA.-GLUTAMYL-

Systematic Name

English

FOXY 5 [WHO-DD]

Common Name

English

Code System Code Type Description

EVMPD

SUB193858