PIPRADIMADOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H37ClN2O2
Molecular Weight	421.016
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C1CCCCC1)C(=O)C(C)(C)C2(O)CCN(CCC3=C(Cl)C=CC=C3)CC2

InChI

InChIKey=CNIMNQJXZKALLC-UHFFFAOYSA-N

InChI=1S/C24H37ClN2O2/c1-23(2,22(28)26(3)20-10-5-4-6-11-20)24(29)14-17-27(18-15-24)16-13-19-9-7-8-12-21(19)25/h7-9,12,20,29H,4-6,10-11,13-18H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C24H37ClN2O2
Molecular Weight	421.016
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6181982 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf | DOI: 10.1007/BF00771998 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 991, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Pipradimadol is a 4.4-disubstituted piperidine derivative which demonstrates, in animal experiments, effects typical for certain antidepressant and antiserotonin drugs. Pipradimadol is the central serotonin antagonist. Pipradimadol exhibits antinociceptive properties also. Behavioral tests reflect overall sedation after pipradimadol, decreased rectal temperature and locomotor activity; cataleptic effects of tetrabenazine are antagonized and noradrenaline as well as dopamine reuptake in vitro are slightly inhibited. Homovanillic acid, a metabolite of dopamine is strongly increased after pipradimadol in rat striatum. Pipradimadol was used as analgesic agent.

Approval Year

PubMed

Title	Date	PubMed
Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties.	1983-01	6600791
Human EEG slow-wave sleep increased by a serotonin antagonist.	1982-11	6181982

Sample Use Guides

In Vivo Use Guide

200 mg was taken nightly for 6 nights

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:06:30 GMT 2025` Edited by `admin` on `Mon Mar 31 18:06:30 GMT 2025`
Record UNII	CBI6614BOL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(O-CHLOROPHENETHYL)-N-CYCLOHEXYL-4-HYDROXY-N,.ALPHA.,.ALPHA.-TRIMETHYL-4-PIPERIDINEACETAMIDE

Preferred Name

English

PIPRADIMADOL

Official Name

English

pipradimadol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C267