BERTOSAMIL

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H36N2
Molecular Weight	292.5025
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CN1C[C@H]2CN(C[C@H](C1)[C@@]23CCCCC3)C(C)C

InChI

InChIKey=AOIVZQPSIHOHMP-ROUUACIJSA-N

InChI=1S/C19H36N2/c1-15(2)10-20-11-17-13-21(16(3)4)14-18(12-20)19(17)8-6-5-7-9-19/h15-18H,5-14H2,1-4H3/t17-,18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H36N2
Molecular Weight	292.5025
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12208779 | https://www.ncbi.nlm.nih.gov/pubmed/9313938 | https://adisinsight.springer.com/drugs/800001582

Bertosamil was developed as an anti-ischemic and anti-arrhythmic drug that inhibits the atrial potassium channels Kv1.2, Kv1.4 and Kv1.5. However, the development of this drug has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.	1995 Aug 4	7589202
Inhibition by bertosamil of cardiac responses to pinacidil or Bay k 8644 in isolated dog atria and ventricles.	1996 Aug 1	8864693

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:25:13 GMT 2023` Edited by `admin` on `Sat Dec 16 17:25:13 GMT 2023`
Record UNII	CB7433DY2H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BERTOSAMIL

Official Name

English

bertosamil [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793