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Details

Stereochemistry ACHIRAL
Molecular Formula C17H20N2O2S
Molecular Weight 316.418
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TINORIDINE

SMILES

CCOC(=O)C1=C(N)SC2=C1CCN(CC3=CC=CC=C3)C2

InChI

InChIKey=PFENFDGYVLAFBR-UHFFFAOYSA-N
InChI=1S/C17H20N2O2S/c1-2-21-17(20)15-13-8-9-19(11-14(13)22-16(15)18)10-12-6-4-3-5-7-12/h3-7H,2,8-11,18H2,1H3

HIDE SMILES / InChI

Molecular Formula C17H20N2O2S
Molecular Weight 316.418
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: http://www.obatapasaja.com/2015/05/komposisi-dosis-dan-harga-nonflamin.html http://www.ncbi.nlm.nih.gov/pubmed/702946

Tinoridine is a non-steroidal anti-inflammatory and analgesic agent. This agent has been proved pharmacologically to show antiedematous and analgesic actions. The mechanism of the anti-inflammatory action of Tinoridine is attributed to its biomembrane stabilizing action particularly on the lysosomes which are related to cell or tissue damage at the time of inflammation through the release of hydrolytic enzymes. Tinoridine may produce gastrointestinal disorders (nausea, loss of appetite, diarrhea, and constipation), vertigo drowsiness, dry mouth and itching.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Nonflamin

Approved Use

Tinoridine is indicated as anti-inflammatory agent after surgery injuries or injury in urology.
Primary
Nonflamin

Approved Use

Tinoridine is used to treat pharyngitis, laryngitis, tonsillitis.
Primary
Nonflamin

Approved Use

For analgesic purpose, Tinoridine is used to treat back pain.
Primary
Nonflamin

Approved Use

For analgesic purpose, Tinoridine is used to treat lumbago.
Primary
Nonflamin

Approved Use

Tinoridine is indicated to treat pain in chronic rheumatic diseases.
PubMed

PubMed

TitleDatePubMed
Ethyl 2-amino-6-benzyl-4,5,6,7-tetra-hydro-thieno[2,3-c]pyridine-3-carboxyl-ate.
2010 Dec 24
Patents

Patents

Sample Use Guides

1-2 capsules 3 times a day
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Tinoridine, at concentrations from 5 microM up to 100 microM, produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 microM ascorbic acid in the renin granule fraction. http://www.ncbi.nlm.nih.gov/pubmed/3906080
30 uM of Tinoridine HCl hydrochloride inhibited the Phospholipase C-induced lysosomal enzyme release from rat liver lysosomes.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:45:56 GMT 2023
Edited
by admin
on Fri Dec 15 15:45:56 GMT 2023
Record UNII
C9Z9ICZ7YR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TINORIDINE
INN   MI   WHO-DD  
INN  
Official Name English
tinoridine [INN]
Common Name English
Y-3642
Code English
NSC-158555
Code English
Tinoridine [WHO-DD]
Common Name English
Y 3642
Code English
TINORIDINE [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
Code System Code Type Description
MERCK INDEX
m1263
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY Merck Index
EVMPD
SUB11077MIG
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
SMS_ID
100000077227
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
DRUG CENTRAL
2672
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
NSC
158555
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
FDA UNII
C9Z9ICZ7YR
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
NCI_THESAURUS
C76821
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
CAS
24237-54-5
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
INN
3079
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
ChEMBL
CHEMBL592943
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
DRUG BANK
DB13001
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
MESH
C100290
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
PUBCHEM
5480
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
ECHA (EC/EINECS)
246-102-0
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
EPA CompTox
DTXSID9023677
Created by admin on Fri Dec 15 15:45:56 GMT 2023 , Edited by admin on Fri Dec 15 15:45:56 GMT 2023
PRIMARY
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