Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H15N5O3 |
| Molecular Weight | 253.2578 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC2=C(N=CN2C[C@H](CO)CCO)C(=O)N1
InChI
InChIKey=SCBFBAWJWLXVHS-ZCFIWIBFSA-N
InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)3-6(4-17)1-2-16/h5-6,16-17H,1-4H2,(H3,11,13,14,18)/t6-/m1/s1
| Molecular Formula | C10H15N5O3 |
| Molecular Weight | 253.2578 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Omaciclovir (previously known as H2G), a cyclic guanosine analog that is structurally similar to acyclovir and was in clinical development for the treatment of herpesvirus infections. This drug acted against varicella-zoster virus (VZV), by the formation of high concentrations of relatively stable H2G-triphosphate, which is a potent inhibitor of the viral DNA polymerases. However, further development of this drug was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Activity of H2G on human herpesvirus-6B strains either sensitive or resistant to ganciclovir. | 2010-06 |
|
| Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells. | 2009-09 |
|
| The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil. | 1998-12 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 06:54:13 GMT 2025
by
admin
on
Wed Apr 02 06:54:13 GMT 2025
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| Record UNII |
C9H909GLI3
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29575
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admin on Wed Apr 02 06:54:13 GMT 2025 , Edited by admin on Wed Apr 02 06:54:13 GMT 2025
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NCI_THESAURUS |
C281
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admin on Wed Apr 02 06:54:13 GMT 2025 , Edited by admin on Wed Apr 02 06:54:13 GMT 2025
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124265-89-0
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CHEMBL2105375
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LL-14
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7982
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300000034270
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135433609
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DTXSID20869696
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C9H909GLI3
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C90785
Created by
admin on Wed Apr 02 06:54:13 GMT 2025 , Edited by admin on Wed Apr 02 06:54:13 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET ORGANISM->INHIBITOR |
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PRODRUG -> METABOLITE ACTIVE |
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ACTIVE MOIETY |
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