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Details

Stereochemistry ACHIRAL
Molecular Formula FO3P.2Na
Molecular Weight 143.9499
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM MONOFLUOROPHOSPHATE

SMILES

[Na+].[Na+].[O-]P([O-])(F)=O

InChI

InChIKey=BFDWBSRJQZPEEB-UHFFFAOYSA-L
InChI=1S/FH2O3P.2Na/c1-5(2,3)4;;/h(H2,2,3,4);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula FO3P
Molecular Weight 97.9704
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Monofluorophosphate (MFP) is an anion, which is a phosphate group with one oxygen atom substituted with a fluorine atom. Sodium Monofluorophosphate is intended to be used by both petitioners in food supplements as a source of fluoride in the forms of multi-vitamin, multi-mineral supplements, solid tablets or tablets dispersible in liquid. The toxic effects of Monofluorophosphate are attributable to the fluoride ion released by the in vivo hydrolysis of the parent compound. The Monofluorophosphate ion appears to play no role. The acute toxicity of Monofluorophosphate is somewhat less than that of NaF, due to the lesser availability of fluoride in the short term from Monofluorophosphate. In the long term, Monofluorophosphate produces virtually the same picture of renal effects and skeletal storage of fluoride as does NaF. Sodium Monofluorophosphate dissociates into sodium and Monofluorophosphate ions in the intestinal tract, the latter being absorbed mainly in the upper small intestine.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
3.4 mM [Ki]
69.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
AMERFRESH

Approved Use

helps potect against cavities.

Launch Date

1996
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 14:59:05 GMT 2023
Edited
by admin
on Fri Dec 15 14:59:05 GMT 2023
Record UNII
C810JCZ56Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM MONOFLUOROPHOSPHATE
INCI   MART.   ORANGE BOOK   USP  
INCI  
Official Name English
Disodium phosphorofluoridate
Systematic Name English
SODIUM MONOFLUOROPHOSPHATE [ORANGE BOOK]
Common Name English
SODIUM MONOFLUOROPHOSPHATE [MART.]
Common Name English
SODIUM MONOFLUOROPHOSPHATE [USP MONOGRAPH]
Common Name English
Sodium fluorophosphate [WHO-DD]
Common Name English
SODIUM FLUOROPHOSPHATE
WHO-DD  
Systematic Name English
NSC-248
Code English
SODIUM MONOFLUOROPHOSPHATE [USP-RS]
Common Name English
SODIUM MONOFLUOROPHOSPHATE [INCI]
Common Name English
PHOSPHOROFLUORIDIC ACID, DISODIUM SALT
Common Name English
Classification Tree Code System Code
CFR 21 CFR 355.70
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
WHO-VATC QA12CD02
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
WHO-VATC QA01AA02
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
CFR 21 CFR 355.20
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
CFR 21 CFR 355.10
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
CFR 21 CFR 355.55
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
WHO-ATC A12CD02
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
WHO-ATC A01AA02
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
CFR 21 CFR 355.50
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
Code System Code Type Description
WIKIPEDIA
SODIUM MONOFLUOROPHOSPHATE
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
RXCUI
56501
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY RxNorm
FDA UNII
C810JCZ56Q
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
CONCEPT Dietary Supplement
DRUG BANK
DB09484
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
PUBCHEM
24266
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
DRUG CENTRAL
4252
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
CAS
10163-15-2
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
RS_ITEM_NUM
1614419
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
CHEBI
86431
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
DAILYMED
C810JCZ56Q
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
EPA CompTox
DTXSID70872554
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
ECHA (EC/EINECS)
233-433-0
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
SMS_ID
100000127430
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
NSC
248
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
NCI_THESAURUS
C61945
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
MESH
C012980
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
ChEMBL
CHEMBL1908359
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
EVMPD
SUB33441
Created by admin on Fri Dec 15 14:59:05 GMT 2023 , Edited by admin on Fri Dec 15 14:59:05 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY