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Details

Stereochemistry ACHIRAL
Molecular Formula FO3P
Molecular Weight 97.9704
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of MONOFLUOROPHOSPHATE ION

SMILES

[O-]P([O-])(F)=O

InChI

InChIKey=DWYMPOCYEZONEA-UHFFFAOYSA-L
InChI=1S/FH2O3P/c1-5(2,3)4/h(H2,2,3,4)/p-2

HIDE SMILES / InChI

Molecular Formula FH2O3P
Molecular Weight 99.9862
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Monofluorophosphate (MFP) is an anion, which is a phosphate group with one oxygen atom substituted with a fluorine atom. Sodium Monofluorophosphate is intended to be used by both petitioners in food supplements as a source of fluoride in the forms of multi-vitamin, multi-mineral supplements, solid tablets or tablets dispersible in liquid. The toxic effects of Monofluorophosphate are attributable to the fluoride ion released by the in vivo hydrolysis of the parent compound. The Monofluorophosphate ion appears to play no role. The acute toxicity of Monofluorophosphate is somewhat less than that of NaF, due to the lesser availability of fluoride in the short term from Monofluorophosphate. In the long term, Monofluorophosphate produces virtually the same picture of renal effects and skeletal storage of fluoride as does NaF. Sodium Monofluorophosphate dissociates into sodium and Monofluorophosphate ions in the intestinal tract, the latter being absorbed mainly in the upper small intestine.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
3.4 mM [Ki]
69.0 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
AMERFRESH

Patents

Substance Class Chemical
Record UNII
4964UZ79MI
Record Status Validated (UNII)
Record Version