Therapy should be initiated with a dose of 0.5-1.0 mg/kg given as a slow intravenous injection (not faster than 12.5 mg/min); further doses of 0.5 mg/kg may be given similarly every 30 min until a satisfactory response is achieved or a total initial dose of 3.0 mg/kg is reached. Alternatively treatment may be initiated as an infusion at a rate of 90 ug/kg/min administered over 10-30 min until the required haemodynamic response is achieved. To maintain the effects the initial dose (not more than 3.0 mg/kg) may be repeated as required every 3-6 h and adjusted according to the response of the patient. Alternatively, a continuous or intermittent infusion at a rate of 5-20 ug/kg/min may be instituted. The total dose over 24 h should not normally exceed 24.0 mg/kg.

Rat cardiac myocytes were incubated with 0.5 mM enoximone for 10 min at 37C and the effect of the drug on PDH activity was measured. Concentrations of 0.01, 0.05, 0.1, 0.25, 0.5 mM were used in assay, which was used to investigate the effect of enoximone on the oxidation of glucose and pyruvate.