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Details

Stereochemistry ABSOLUTE
Molecular Formula C11H13BrN2O6
Molecular Weight 349.135
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of SORIVUDINE

SMILES

OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=C(\C=C\Br)C(=O)NC2=O

InChI

InChIKey=GCQYYIHYQMVWLT-HQNLTJAPSA-N
InChI=1S/C11H13BrN2O6/c12-2-1-5-3-14(11(19)13-9(5)18)10-8(17)7(16)6(4-15)20-10/h1-3,6-8,10,15-17H,4H2,(H,13,18,19)/b2-1+/t6-,7-,8+,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula C11H13BrN2O6
Molecular Weight 349.135
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 1
Optical Activity UNSPECIFIED

Description

SORIVUDINE (BV-araU) is an Anti-Herpes Virus Drugs, which was Withdrawn in 1995. Aantiviral action of BV-araU against VZV (varicella-zoster virus) and herpes simplex virus type 1 (HSV-1) is based on the inhibition of DNA synthesis in herpesvirus-infected cells.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
for mice: 5% BV-araU (SORIVUDINE) cream given 4 times daily for 5 days starting 1 day after inoculation
Route of Administration: Topical
In Vitro Use Guide
The inhibitory effect of BV-araU (SORIVUDINE) on DNA synthesis in human embryonic lung cells infected with varicella-zoster virus (VZV) or herpes simplex virus type 1 (HSV-1) was compared with that of acyclovir. he inhibitory concentration of BV-araU for DNA synthesis in VZV-infected cells was one-thousandth of that of acyclovir.
Substance Class Chemical
Record UNII
C7VOZ162LV
Record Status Validated (UNII)
Record Version