SEQUIFENADINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H27NO
Molecular Weight	321.4559
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=CC=C1C(O)(C2CN3CCC2CC3)C4=CC=CC=C4C

InChI

InChIKey=OXDOWGVJMITMJL-UHFFFAOYSA-N

InChI=1S/C22H27NO/c1-16-7-3-5-9-19(16)22(24,20-10-6-4-8-17(20)2)21-15-23-13-11-18(21)12-14-23/h3-10,18,21,24H,11-15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C22H27NO
Molecular Weight	321.4559
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.degruyter.com/downloadpdf/j/prolas.2010.64.issue-5-6/v10046-011-0001-9/v10046-011-0001-9.pdf | https://36i6.info/sehifenadin-sequifenadine/ | https://www.ncbi.nlm.nih.gov/pubmed/2575827

Sequifenadine is H1- and 5HT-serotonine receptor antagonist. It has an anti-histamine effect, not only blocking histamine receptors, but also reducing the content of histamine in tissues by accelerating its destruction by diamine oxidase. Sequifenadine did not demonstrate any significant sedative effect. It has a pronounced and prolonged antipruritic and antiexudative effect. It is indicated for the treatment of allergic rhinitis and conjunctivitis, pollinosis, urticaria, angioedema, allergic pruritic dermatosis, including atopic dermatitis. Adverse effects are: dry mouth, pain in the epigastric region, dyspepsia, increased appetite, headache, sleepiness.

Approval Year

Sample Use Guides

In Vivo Use Guide

50-100 mg 2-3 times per day. The course of treatment is 5-15 days.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Wed Apr 02 07:29:39 GMT 2025` Edited by `admin` on `Wed Apr 02 07:29:39 GMT 2025`
Record UNII	C7Q3TBR3FP
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SEQUIFENADINE [MART.]

Preferred Name

English

SEQUIFENADINE

Official Name

English

Sequifenadine [WHO-DD]

Common Name

English

sequifenadine [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QR06AX32