GLUNICATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C36H28N6O10
Molecular Weight	704.6417
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(N[C@H]1[C@H](OC(=O)C2=CC=CN=C2)O[C@H](COC(=O)C3=CC=CN=C3)[C@@H](OC(=O)C4=CC=CN=C4)[C@@H]1OC(=O)C5=CC=CN=C5)C6=CC=CN=C6

InChI

InChIKey=ZLNMZWDQJJAEAM-QPBDZWBWSA-N

InChI=1S/C36H28N6O10/c43-31(22-6-1-11-37-16-22)42-28-30(51-34(46)25-9-4-14-40-19-25)29(50-33(45)24-8-3-13-39-18-24)27(21-48-32(44)23-7-2-12-38-17-23)49-36(28)52-35(47)26-10-5-15-41-20-26/h1-20,27-30,36H,21H2,(H,42,43)/t27-,28-,29-,30-,36+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C36H28N6O10
Molecular Weight	704.6417
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2868101 | https://www.ncbi.nlm.nih.gov/pubmed/6138406 | https://www.ncbi.nlm.nih.gov/pubmed/6238601

Glunicate (LG 13979) is a long-acting nicotinic acid derivative that can lower plasma triglyceride levels, while leaving other lipoprotein parameters unaffected. It exerts a dose‐dependent reduction of plasma triglycerides and cholesterol. In rabbits, glunicate provided dose-dependent protection of the arterial wall from atheromatous lesions and from cholesterol and collagen accumulation. It has been shown that glunicate has prolonged activity on plasma free fatty acids and triglycerides, with long lasting and intense activity on plasma cholesterol.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:08:45 GMT 2023` Edited by `admin` on `Fri Dec 15 16:08:45 GMT 2023`
Record UNII	C62ZH19B0L
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GLUNICATE

Official Name

English

glunicate [INN]

Common Name

English

2-DEOXY-2-NICOTINAMIDO-.BETA.-D-GLUCOPYRANOSE 1,3,4,6-TETRANICOTINATE

Common Name

English

GLUNICATE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98151